PDF(Pubmed)
Abstract：
UNASSIGNED: One of the ailments with the greatest fatality rates in the 21st century is cancer. Globally, molecular methods are widely employed to treat cancer-related disorders, and the body of research on this subject is growing yearly. A thorough and critical summary of the data supporting molecular methods for illnesses linked to cancer is required.
UNASSIGNED: In order to guide clinical practice and future research, it is important to examine and summarize the systematic reviews (SRs) that evaluate the efficacy and safety of molecular methods for disorders associated to cancer.
UNASSIGNED: We developed a comprehensive search strategy to find relevant articles from electronic databases like PubMed, Google Scholar, Web of Science (WoS), or Scopus. We looked through the literature and determined which diagnostic methods in cancer genetics were particularly reliable. We used phrases like \'cancer genetics\', genetic susceptibility, Hereditary cancer, cancer risk assessment, \'cancer diagnostic tools\', cancer screening\', biomarkers, and molecular diagnostics, reviews and meta-analyses evaluating the efficacy and safety of molecular therapies for cancer-related disorders. Research that only consider treatment modalities that don\'t necessitate genetic or molecular diagnostics fall under the exclusion criteria.
UNASSIGNED: The results of this comprehensive review clearly demonstrate the transformative impact of molecular methods in the realm of cancer genetics.This review underscores how these technologies have empowered researchers and clinicians to identify and understand key genetic alterations that drive malignancy, ranging from point mutations to structural variations. Such insights are instrumental in pinpointing critical oncogenic drivers and potential therapeutic targets, thus opening the door for methods in precision medicine that can significantly improve patient outcomes.
UNASSIGNED: The search does not specify a timeframe for publication inclusion, it may have missed recent advancements or changes in the field\'s landscape of molecular methods for cancer. As a result, it may not have included the most recent developments in the field.
UNASSIGNED: After conducting an in-depth study on the molecular methods in cancer genetics, it is evident that these cutting-edge technologies have revolutionized the field of oncology, providing researchers and clinicians with powerful tools to unravel the complexities of cancer at the genetic level. The integration of molecular methods techniques has not only enhanced our understanding of cancer etiology, progression, and treatment response but has also opened new avenues for personalized medicine and targeted therapies, leading to improved patient outcomes.
UNASSIGNED: In order to guide clinical practice and future research, it is important to examine and summarize the systematic reviews (SRs) that evaluate the efficacy and safety of molecular methods for disorders associated to cancer.
UNASSIGNED: We developed a comprehensive search strategy to find relevant articles from electronic databases like PubMed, Google Scholar, Web of Science (WoS), or Scopus. We looked through the literature and determined which diagnostic methods in cancer genetics were particularly reliable. We used phrases like \'cancer genetics\', genetic susceptibility, Hereditary cancer, cancer risk assessment, \'cancer diagnostic tools\', cancer screening\', biomarkers, and molecular diagnostics, reviews and meta-analyses evaluating the efficacy and safety of molecular therapies for cancer-related disorders. Research that only consider treatment modalities that don\'t necessitate genetic or molecular diagnostics fall under the exclusion criteria.
UNASSIGNED: The results of this comprehensive review clearly demonstrate the transformative impact of molecular methods in the realm of cancer genetics.This review underscores how these technologies have empowered researchers and clinicians to identify and understand key genetic alterations that drive malignancy, ranging from point mutations to structural variations. Such insights are instrumental in pinpointing critical oncogenic drivers and potential therapeutic targets, thus opening the door for methods in precision medicine that can significantly improve patient outcomes.
UNASSIGNED: The search does not specify a timeframe for publication inclusion, it may have missed recent advancements or changes in the field\'s landscape of molecular methods for cancer. As a result, it may not have included the most recent developments in the field.
UNASSIGNED: After conducting an in-depth study on the molecular methods in cancer genetics, it is evident that these cutting-edge technologies have revolutionized the field of oncology, providing researchers and clinicians with powerful tools to unravel the complexities of cancer at the genetic level. The integration of molecular methods techniques has not only enhanced our understanding of cancer etiology, progression, and treatment response but has also opened new avenues for personalized medicine and targeted therapies, leading to improved patient outcomes.
摘要：
21世纪死亡率最高的疾病之一是癌症。全球范围内,分子方法被广泛用于治疗癌症相关疾病，关于这个主题的研究机构每年都在增长。需要对支持与癌症有关的疾病的分子方法的数据进行全面而重要的总结。
■为了指导临床实践和未来的研究，重要的是检查和总结评估分子方法治疗癌症相关疾病的有效性和安全性的系统评价(SRs).
■我们开发了一种全面的搜索策略，可以从PubMed等电子数据库中查找相关文章，谷歌学者，WebofScience(WoS),或者Scopus.我们浏览了文献，并确定了癌症遗传学中哪些诊断方法特别可靠。我们使用了像“癌症遗传学”这样的短语，遗传易感性,遗传性癌症,癌症风险评估，\'癌症诊断工具\',癌症筛查，生物标志物，和分子诊断，综述和荟萃分析评估分子疗法对癌症相关疾病的疗效和安全性。仅考虑不需要遗传或分子诊断的治疗方式的研究属于排除标准。
■这篇综合综述的结果清楚地证明了分子方法在癌症遗传学领域的转化作用。这篇综述强调了这些技术如何使研究人员和临床医生能够识别和理解导致恶性肿瘤的关键遗传改变。从点突变到结构变异。这些见解有助于确定关键的致癌驱动因素和潜在的治疗目标，从而为能够显著改善患者预后的精准医学方法打开了大门。
■搜索没有指定包含出版物的时间表，它可能错过了癌症分子方法领域的最新进展或变化。因此,它可能没有包括该领域的最新发展。
■在对癌症遗传学中的分子方法进行了深入研究之后，很明显，这些尖端技术彻底改变了肿瘤学领域，为研究人员和临床医生提供强大的工具，在基因水平上解开癌症的复杂性。分子方法技术的整合不仅增强了我们对癌症病因的理解，programming,和治疗反应，但也为个性化医疗和靶向治疗开辟了新的途径，改善患者预后。
■为了指导临床实践和未来的研究，重要的是检查和总结评估分子方法治疗癌症相关疾病的有效性和安全性的系统评价(SRs).
■我们开发了一种全面的搜索策略，可以从PubMed等电子数据库中查找相关文章，谷歌学者，WebofScience(WoS),或者Scopus.我们浏览了文献，并确定了癌症遗传学中哪些诊断方法特别可靠。我们使用了像“癌症遗传学”这样的短语，遗传易感性,遗传性癌症,癌症风险评估，\'癌症诊断工具\',癌症筛查，生物标志物，和分子诊断，综述和荟萃分析评估分子疗法对癌症相关疾病的疗效和安全性。仅考虑不需要遗传或分子诊断的治疗方式的研究属于排除标准。
■这篇综合综述的结果清楚地证明了分子方法在癌症遗传学领域的转化作用。这篇综述强调了这些技术如何使研究人员和临床医生能够识别和理解导致恶性肿瘤的关键遗传改变。从点突变到结构变异。这些见解有助于确定关键的致癌驱动因素和潜在的治疗目标，从而为能够显著改善患者预后的精准医学方法打开了大门。
■搜索没有指定包含出版物的时间表，它可能错过了癌症分子方法领域的最新进展或变化。因此,它可能没有包括该领域的最新发展。
■在对癌症遗传学中的分子方法进行了深入研究之后，很明显，这些尖端技术彻底改变了肿瘤学领域，为研究人员和临床医生提供强大的工具，在基因水平上解开癌症的复杂性。分子方法技术的整合不仅增强了我们对癌症病因的理解，programming,和治疗反应，但也为个性化医疗和靶向治疗开辟了新的途径，改善患者预后。
