Abstract：
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common forms of arthritis with undefined etiology and pathogenesis. Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ), which act as sensors for cellular mechanical and inflammatory cues, have been identified as crucial players in the regulation of joint homeostasis. Current studies also reveal a significant association between YAP/TAZ and the pathogenesis of OA and RA. The objective of this review is to elucidate the impact of YAP/TAZ on different joint tissues and to provide inspiration for further studying the potential therapeutic implications of YAP/TAZ on arthritis. Databases, such as PubMed, Cochran Library, and Embase, were searched for all available studies during the past two decades, with keywords \"YAP,\" \"TAZ,\" \"OA,\" and \"RA.\"
摘要：
骨关节炎（OA）和类风湿性关节炎（RA）是两种常见的关节炎形式，病因和发病机制不明确。Yes相关蛋白(YAP)及其同源转录共激活因子与PDZ结合基序(TAZ),作为细胞机械和炎症信号的传感器，已被确定为调节联合体内平衡的关键参与者。目前的研究还揭示了YAP/TAZ与OA和RA的发病机制之间的显著关联。这篇综述的目的是阐明YAP/TAZ对不同关节组织的影响，并为进一步研究YAP/TAZ对关节炎的潜在治疗意义提供启发。数据库,比如PubMed,Cochran图书馆,和Embase,在过去的二十年中搜索了所有可用的研究，关键字\"YAP,\"\"TAZ,\"\"OA,\"和\"RA。\"
