PDF(Pubmed)
Abstract：
UNASSIGNED: Research data suggests that ultrasound-assisted wound debridement (UAWD) can effectively promote the healing of diabetic foot ulcers (DFU). However, existing research is not consistent with this viewpoint. Therefore, we conducted this study to investigate the effect of UAWD on the healing of diabetic foot ulcers.
UNASSIGNED: From the establishment of the database to January 2024, we searched 8 databases to study the effectiveness and safety of UAWD in the treatment of DFU. Two authors independently screened the qualifications of the articles, while two authors extracted relevant data. Statistical analysis was conducted using Review Manager 5.4 and STATA 18.0 software.
UNASSIGNED: A total of 11 randomized controlled studies were included, with 6 countries and 696 participants participating. Our findings showed that UAWD was associated with a significant benefit in healing rate (OR = 2.60, 95% CI: [1.67, 4.03], P < 0.0001, I2 = 25%), wound healing time (MD = -11.94, 95% CI: [-23.65, -0.23], P = 0.05, I2 = 99%), percentage reduction in wound size (MD = 14.2, 95% CI: [10.8, 17.6], P = 0.47, I2 = 32%), effectiveness of treatment (OR = 10.3, 95% CI: [4.68, 22.66], P < 0.00001, I2 = 0%). Moreover, UAWD did not cause any significant adverse reactions. However, there was no obvious difference in wound blood perfusion (MD = 0.25, 95% CI: [-0.01, 0.52], P = 0.06, I2 = 90%), transcutaneous oxygen partial pressure (MD = 14.34, 95% CI: [-10.03, 38.71], P = 0.25, I2 = 98%).
UNASSIGNED: UAWD can significantly improve wound healing rate, shorten wound healing time, accelerate wound area reduction, and improve clinical treatment effectiveness without significant adverse reactions. Although there is no significant difference in transcutaneous oxygen pressure and wound blood flow perfusion between UAWD and SWC. So we look forward to more scientifically blinded, placebo-controlled, high-quality studies in the future, to enable researchers to obtain more complete and accurate analytical data, in order to improve the scientific and credibility of the evidence.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42024501198.
UNASSIGNED: From the establishment of the database to January 2024, we searched 8 databases to study the effectiveness and safety of UAWD in the treatment of DFU. Two authors independently screened the qualifications of the articles, while two authors extracted relevant data. Statistical analysis was conducted using Review Manager 5.4 and STATA 18.0 software.
UNASSIGNED: A total of 11 randomized controlled studies were included, with 6 countries and 696 participants participating. Our findings showed that UAWD was associated with a significant benefit in healing rate (OR = 2.60, 95% CI: [1.67, 4.03], P < 0.0001, I2 = 25%), wound healing time (MD = -11.94, 95% CI: [-23.65, -0.23], P = 0.05, I2 = 99%), percentage reduction in wound size (MD = 14.2, 95% CI: [10.8, 17.6], P = 0.47, I2 = 32%), effectiveness of treatment (OR = 10.3, 95% CI: [4.68, 22.66], P < 0.00001, I2 = 0%). Moreover, UAWD did not cause any significant adverse reactions. However, there was no obvious difference in wound blood perfusion (MD = 0.25, 95% CI: [-0.01, 0.52], P = 0.06, I2 = 90%), transcutaneous oxygen partial pressure (MD = 14.34, 95% CI: [-10.03, 38.71], P = 0.25, I2 = 98%).
UNASSIGNED: UAWD can significantly improve wound healing rate, shorten wound healing time, accelerate wound area reduction, and improve clinical treatment effectiveness without significant adverse reactions. Although there is no significant difference in transcutaneous oxygen pressure and wound blood flow perfusion between UAWD and SWC. So we look forward to more scientifically blinded, placebo-controlled, high-quality studies in the future, to enable researchers to obtain more complete and accurate analytical data, in order to improve the scientific and credibility of the evidence.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42024501198.
摘要：
■研究数据表明，超声辅助伤口清创（UAWD）可有效促进糖尿病足溃疡（DFU）的愈合。然而,现有研究与这一观点并不一致。因此,本研究旨在探讨UAWD对糖尿病足溃疡愈合的影响.
■从数据库建立到2024年1月，我们搜索了8个数据库，以研究UAWD治疗DFU的有效性和安全性。两位作者独立筛选了文章的资格，而两位作者提取了相关数据。使用ReviewManager5.4和STATA18.0软件进行统计分析。
■共纳入11项随机对照研究，有6个国家和696名参与者参加。我们的研究结果表明，UAWD与治愈率显着相关（OR=2.60，95％CI：[1.67，4.03]，P<0.0001,I2=25%),伤口愈合时间（MD=-11.94，95%CI：[-23.65，-0.23]，P=0.05，I2=99%），伤口大小减少的百分比（MD=14.2，95%CI：[10.8，17.6]，P=0.47，I2=32%），治疗有效性（OR=10.3，95%CI：[4.68，22.66]，P<0.00001,I2=0%)。此外，UAWD没有引起任何明显的不良反应。然而,伤口血液灌注无明显差异(MD=0.25,95%CI:[-0.01,0.52],P=0.06,I2=90%),经皮氧分压（MD=14.34，95%CI：[-10.03，38.71]，P=0.25，I2=98%）。
■UAWD可以显着提高伤口愈合率，缩短伤口愈合时间，加速伤口面积减少，提高临床治疗效果,无明显不良反应。尽管UAWD和SWC之间的经皮氧分压和伤口血流灌注没有显着差异。所以我们期待更科学的蒙蔽，安慰剂对照,未来高质量的研究，为了使研究人员能够获得更完整和准确的分析数据，以提高证据的科学性和可信度。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42024501198。
■从数据库建立到2024年1月，我们搜索了8个数据库，以研究UAWD治疗DFU的有效性和安全性。两位作者独立筛选了文章的资格，而两位作者提取了相关数据。使用ReviewManager5.4和STATA18.0软件进行统计分析。
■共纳入11项随机对照研究，有6个国家和696名参与者参加。我们的研究结果表明，UAWD与治愈率显着相关（OR=2.60，95％CI：[1.67，4.03]，P<0.0001,I2=25%),伤口愈合时间（MD=-11.94，95%CI：[-23.65，-0.23]，P=0.05，I2=99%），伤口大小减少的百分比（MD=14.2，95%CI：[10.8，17.6]，P=0.47，I2=32%），治疗有效性（OR=10.3，95%CI：[4.68，22.66]，P<0.00001,I2=0%)。此外，UAWD没有引起任何明显的不良反应。然而,伤口血液灌注无明显差异(MD=0.25,95%CI:[-0.01,0.52],P=0.06,I2=90%),经皮氧分压（MD=14.34，95%CI：[-10.03，38.71]，P=0.25，I2=98%）。
■UAWD可以显着提高伤口愈合率，缩短伤口愈合时间，加速伤口面积减少，提高临床治疗效果,无明显不良反应。尽管UAWD和SWC之间的经皮氧分压和伤口血流灌注没有显着差异。所以我们期待更科学的蒙蔽，安慰剂对照,未来高质量的研究，为了使研究人员能够获得更完整和准确的分析数据，以提高证据的科学性和可信度。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42024501198。
