PDF(Pubmed)
Abstract：
UNASSIGNED: The objective of this study was to explore the association between the ratio of serum creatinine to cystatin C to waist circumference (CCR/WC) and hypertension.
UNASSIGNED: The study utilized data extracted from the China Health and Retirement Longitudinal Study. In the cross-sectional analysis, logistic regression analyses were employed to examine the association between the CCR/WC ratio and hypertension. By utilizing restricted cubic splines, potential non-linear associations between the CCR/WC ratio and hypertension were explored. In the longitudinal analysis, the association between CCR/WC quartiles (Q1-Q4) and the risk of new-onset hypertension was evaluated by Cox proportional-hazards models.
UNASSIGNED: In total, 7,253 participants were enrolled. The study unveiled an inverse association with hypertension, demonstrating an odds ratio (OR) of 0.29 (95% confidence interval [CI]: 0.23-0.37, P < 0.001). Among males, an OR of 0.38 (95% CI: 0.25-0.58, P < 0.001) was observed, while among females, an OR of 0.41 (95% CI: 0.28-0.60, P < 0.001) was noted. There was an absence of a nonlinear association between the CCR/WC ratio and hypertension. Cox regression analysis unveiled a reduced risk of hypertension in Q3 (Hazard ratios [HR]: 0.69, 95% CI: 0.58-0.82, P < 0.001) and Q4: (HR: 0.70, 95% CI: 0.59-0.83, P < 0.001) in compared to the Q1 of the CCR/WC ratio, and sex-specific analysis yielded consistent results.
UNASSIGNED: This study emphasizes the potential association between an elevated CCR/WC ratio and a reduced risk of hypertension.
UNASSIGNED: The study utilized data extracted from the China Health and Retirement Longitudinal Study. In the cross-sectional analysis, logistic regression analyses were employed to examine the association between the CCR/WC ratio and hypertension. By utilizing restricted cubic splines, potential non-linear associations between the CCR/WC ratio and hypertension were explored. In the longitudinal analysis, the association between CCR/WC quartiles (Q1-Q4) and the risk of new-onset hypertension was evaluated by Cox proportional-hazards models.
UNASSIGNED: In total, 7,253 participants were enrolled. The study unveiled an inverse association with hypertension, demonstrating an odds ratio (OR) of 0.29 (95% confidence interval [CI]: 0.23-0.37, P < 0.001). Among males, an OR of 0.38 (95% CI: 0.25-0.58, P < 0.001) was observed, while among females, an OR of 0.41 (95% CI: 0.28-0.60, P < 0.001) was noted. There was an absence of a nonlinear association between the CCR/WC ratio and hypertension. Cox regression analysis unveiled a reduced risk of hypertension in Q3 (Hazard ratios [HR]: 0.69, 95% CI: 0.58-0.82, P < 0.001) and Q4: (HR: 0.70, 95% CI: 0.59-0.83, P < 0.001) in compared to the Q1 of the CCR/WC ratio, and sex-specific analysis yielded consistent results.
UNASSIGNED: This study emphasizes the potential association between an elevated CCR/WC ratio and a reduced risk of hypertension.
摘要：
■这项研究的目的是探讨血清肌酐与胱抑素C的比值与腰围（CCR/WC）与高血压之间的关系。
■该研究利用了从中国健康与退休纵向研究中提取的数据。在横截面分析中，采用logistic回归分析来检验CCR/WC比值与高血压之间的相关性.通过使用受限三次样条，研究了CCR/WC比值与高血压之间的潜在非线性关联.在纵向分析中，我们通过Cox比例风险模型评估了CCR/WC四分位数(Q1-Q4)与新发高血压风险之间的相关性.
■总共，7253名参与者被登记。这项研究揭示了与高血压的负相关，显示比值比（OR）为0.29（95％置信区间[CI]：0.23-0.37，P<0.001）。在男性中，观察到OR为0.38（95％CI：0.25-0.58，P<0.001），而在女性中，OR为0.41（95%CI：0.28-0.60，P<0.001）。CCR/WC比值与高血压之间不存在非线性关联。Cox回归分析显示，与CCR/WC比值的Q1相比，Q3（危险比[HR]：0.69，95％CI：0.58-0.82，P<0.001）和Q4：（HR：0.70，95％CI：0.59-0.83，P<0.001）的高血压风险降低，和性别特异性分析产生一致的结果。
■这项研究强调了CCR/WC比值升高与高血压风险降低之间的潜在关联。
■该研究利用了从中国健康与退休纵向研究中提取的数据。在横截面分析中，采用logistic回归分析来检验CCR/WC比值与高血压之间的相关性.通过使用受限三次样条，研究了CCR/WC比值与高血压之间的潜在非线性关联.在纵向分析中，我们通过Cox比例风险模型评估了CCR/WC四分位数(Q1-Q4)与新发高血压风险之间的相关性.
■总共，7253名参与者被登记。这项研究揭示了与高血压的负相关，显示比值比（OR）为0.29（95％置信区间[CI]：0.23-0.37，P<0.001）。在男性中，观察到OR为0.38（95％CI：0.25-0.58，P<0.001），而在女性中，OR为0.41（95%CI：0.28-0.60，P<0.001）。CCR/WC比值与高血压之间不存在非线性关联。Cox回归分析显示，与CCR/WC比值的Q1相比，Q3（危险比[HR]：0.69，95％CI：0.58-0.82，P<0.001）和Q4：（HR：0.70，95％CI：0.59-0.83，P<0.001）的高血压风险降低，和性别特异性分析产生一致的结果。
■这项研究强调了CCR/WC比值升高与高血压风险降低之间的潜在关联。
