UNASSIGNED: In our meta-analysis, relevant studies published before 20 February 2024 were systematically searched through online databases that included PubMed, Scopus, and Web of Science. The association between FAP-α expression and metastasis, including distant metastasis, lymph node metastasis, blood vessel invasion, vascular invasion, and neural invasion, was evaluated. A pooled odds ratio (OR) with 95% confidence intervals (CI) was reported as the measure of association.
UNASSIGNED: A total of 28meta-analysis. The random-effects model for five parameters showed that a high FAP-α expression was associated with blood vessel invasion (OR: 3.04, 95% CI: 1.54-5.99, I 2 = 63%, P = 0.001), lymphovascular invasion (OR: 3.56, 95% CI: 2.14-5.93, I 2 = 0.00%, P < 0.001), lymph node metastasis (OR: 2.73, 95% CI: 1.96-3.81, I 2 = 65%, P < 0.001), and distant metastasis (OR: 2.59; 95% CI: 1.16-5.79, I 2 = 81%, P < 0.001). However, our analysis showed no statistically significant association between high FAP-α expression and neural invasion (OR: 1.57, 95% CI: 0.84-2.93, I 2 = 38%, P = 0.161).
UNASSIGNED: This meta-analysis indicated that cancer cells with a high FAP-α expression have a higher risk of metastasis than those with a low FAP-α expression. These findings support the potential importance of FAP-α as a biomarker for cancer metastasis prediction.
■在我们的荟萃分析中,在2024年2月20日之前发表的相关研究通过包括PubMed在内的在线数据库进行了系统搜索,Scopus,和WebofScience。FAP-α表达与肿瘤转移的关系,包括远处转移,淋巴结转移,血管侵入,血管浸润,和神经入侵,进行了评估。报告了具有95%置信区间(CI)的合并比值比(OR)作为关联度量。
■共28个荟萃分析。五个参数的随机效应模型表明,高FAP-α表达与血管浸润有关(OR:3.04,95%CI:1.54-5.99,I2=63%,P=0.001),淋巴管浸润(OR:3.56,95%CI:2.14-5.93,I2=0.00%,P<0.001),淋巴结转移(OR:2.73,95%CI:1.96-3.81,I2=65%,P<0.001),和远处转移(OR:2.59;95%CI:1.16-5.79,I2=81%,P<0.001)。然而,我们的分析表明,高FAP-α表达与神经侵袭之间没有统计学上的显着关联(OR:1.57,95%CI:0.84-2.93,I2=38%,P=0.161)。
■该荟萃分析表明,具有高FAP-α表达的癌细胞比具有低FAP-α表达的癌细胞具有更高的转移风险。这些发现支持FAP-α作为癌症转移预测的生物标志物的潜在重要性。