PDF(Pubmed)
Abstract：
UNASSIGNED: Fibroblast activation protein-α (FAP-α) is a vital surface marker of cancer-associated fibroblasts, and its high expression is associated with a higher tumor grade and metastasis. A systematic review and a meta-analysis were performed to associate future metastasis with FAP-α expression in cancer.
UNASSIGNED: In our meta-analysis, relevant studies published before 20 February 2024 were systematically searched through online databases that included PubMed, Scopus, and Web of Science. The association between FAP-α expression and metastasis, including distant metastasis, lymph node metastasis, blood vessel invasion, vascular invasion, and neural invasion, was evaluated. A pooled odds ratio (OR) with 95% confidence intervals (CI) was reported as the measure of association.
UNASSIGNED: A total of 28meta-analysis. The random-effects model for five parameters showed that a high FAP-α expression was associated with blood vessel invasion (OR: 3.04, 95% CI: 1.54-5.99, I 2 = 63%, P = 0.001), lymphovascular invasion (OR: 3.56, 95% CI: 2.14-5.93, I 2 = 0.00%, P < 0.001), lymph node metastasis (OR: 2.73, 95% CI: 1.96-3.81, I 2 = 65%, P < 0.001), and distant metastasis (OR: 2.59; 95% CI: 1.16-5.79, I 2 = 81%, P < 0.001). However, our analysis showed no statistically significant association between high FAP-α expression and neural invasion (OR: 1.57, 95% CI: 0.84-2.93, I 2 = 38%, P = 0.161).
UNASSIGNED: This meta-analysis indicated that cancer cells with a high FAP-α expression have a higher risk of metastasis than those with a low FAP-α expression. These findings support the potential importance of FAP-α as a biomarker for cancer metastasis prediction.
UNASSIGNED: In our meta-analysis, relevant studies published before 20 February 2024 were systematically searched through online databases that included PubMed, Scopus, and Web of Science. The association between FAP-α expression and metastasis, including distant metastasis, lymph node metastasis, blood vessel invasion, vascular invasion, and neural invasion, was evaluated. A pooled odds ratio (OR) with 95% confidence intervals (CI) was reported as the measure of association.
UNASSIGNED: A total of 28meta-analysis. The random-effects model for five parameters showed that a high FAP-α expression was associated with blood vessel invasion (OR: 3.04, 95% CI: 1.54-5.99, I 2 = 63%, P = 0.001), lymphovascular invasion (OR: 3.56, 95% CI: 2.14-5.93, I 2 = 0.00%, P < 0.001), lymph node metastasis (OR: 2.73, 95% CI: 1.96-3.81, I 2 = 65%, P < 0.001), and distant metastasis (OR: 2.59; 95% CI: 1.16-5.79, I 2 = 81%, P < 0.001). However, our analysis showed no statistically significant association between high FAP-α expression and neural invasion (OR: 1.57, 95% CI: 0.84-2.93, I 2 = 38%, P = 0.161).
UNASSIGNED: This meta-analysis indicated that cancer cells with a high FAP-α expression have a higher risk of metastasis than those with a low FAP-α expression. These findings support the potential importance of FAP-α as a biomarker for cancer metastasis prediction.
摘要：
■成纤维细胞激活蛋白-α（FAP-α）是癌症相关成纤维细胞的重要表面标志物，高表达与肿瘤分级和转移有关。进行了系统评价和荟萃分析，以将未来的转移与FAP-α在癌症中的表达联系起来。
■在我们的荟萃分析中，在2024年2月20日之前发表的相关研究通过包括PubMed在内的在线数据库进行了系统搜索，Scopus,和WebofScience。FAP-α表达与肿瘤转移的关系,包括远处转移,淋巴结转移,血管侵入,血管浸润,和神经入侵，进行了评估。报告了具有95％置信区间（CI）的合并比值比（OR）作为关联度量。
■共28个荟萃分析。五个参数的随机效应模型表明，高FAP-α表达与血管浸润有关（OR：3.04，95％CI：1.54-5.99，I2=63％，P=0.001),淋巴管浸润（OR：3.56，95%CI：2.14-5.93，I2=0.00%，P<0.001)，淋巴结转移（OR：2.73，95％CI：1.96-3.81，I2=65％，P<0.001)，和远处转移（OR：2.59；95％CI：1.16-5.79，I2=81％，P<0.001)。然而,我们的分析表明，高FAP-α表达与神经侵袭之间没有统计学上的显着关联（OR：1.57，95％CI：0.84-2.93，I2=38％，P=0.161）。
■该荟萃分析表明，具有高FAP-α表达的癌细胞比具有低FAP-α表达的癌细胞具有更高的转移风险。这些发现支持FAP-α作为癌症转移预测的生物标志物的潜在重要性。
■在我们的荟萃分析中，在2024年2月20日之前发表的相关研究通过包括PubMed在内的在线数据库进行了系统搜索，Scopus,和WebofScience。FAP-α表达与肿瘤转移的关系,包括远处转移,淋巴结转移,血管侵入,血管浸润,和神经入侵，进行了评估。报告了具有95％置信区间（CI）的合并比值比（OR）作为关联度量。
■共28个荟萃分析。五个参数的随机效应模型表明，高FAP-α表达与血管浸润有关（OR：3.04，95％CI：1.54-5.99，I2=63％，P=0.001),淋巴管浸润（OR：3.56，95%CI：2.14-5.93，I2=0.00%，P<0.001)，淋巴结转移（OR：2.73，95％CI：1.96-3.81，I2=65％，P<0.001)，和远处转移（OR：2.59；95％CI：1.16-5.79，I2=81％，P<0.001)。然而,我们的分析表明，高FAP-α表达与神经侵袭之间没有统计学上的显着关联（OR：1.57，95％CI：0.84-2.93，I2=38％，P=0.161）。
■该荟萃分析表明，具有高FAP-α表达的癌细胞比具有低FAP-α表达的癌细胞具有更高的转移风险。这些发现支持FAP-α作为癌症转移预测的生物标志物的潜在重要性。
