Abstract:
Cerebral cavernous malformation is an angiographically occult, well-circumscribed, benign hamartoma consisting of thin-walled sinusoidal vascular channels. Intracranial mucormycosis represents one of the most severe manifestations of mucor infection. We, hereby, report a case of cavernous malformation made rarer with concomitant mucormycosis. A 22-year-old female presented with left-sided facial seizures since age of 7 years and headache for the past 3 years. Magnetic resonance imaging brain revealed a right posterior frontal lobe cavernous malformation. Right frontal craniotomy with excision of cavernoma was done. Gross examination showed a solid cystic mass with multiple mulberry protrusions. Histopathological examination revealed features of cavernous malformation with evidence of mucormycosis. A final diagnosis of cavernous malformation with mucormycosis was rendered and microbiological studies were advised. To the best of our knowledge, this is the first case report of a cerebral cavernous malformation with mucormycosis in an immunocompetent patient without any risk factor.
摘要:
脑海绵状畸形是一种血管造影隐匿性,界限分明,由薄壁正弦血管通道组成的良性错构瘤。颅内毛霉菌病是粘液感染最严重的表现之一。我们,特此,报告一例罕见的海绵状畸形伴发毛霉菌病。一名22岁女性从7岁开始出现左侧面部癫痫发作,并在过去3年中出现头痛。磁共振成像大脑显示右后额叶海绵状畸形。右额开颅切除海绵体瘤。大体检查显示实性囊性肿块,有多个桑树突起。组织病理学检查显示海绵状畸形的特征,并有毛霉菌病的证据。最终诊断为海绵状畸形伴毛霉菌病,并建议进行微生物学研究。据我们所知,这是首例无任何危险因素的免疫功能正常的脑海绵状畸形伴毛霉菌病的病例报告。