Abstract：
OBJECTIVE: To determine the characteristics and risk factors of breast cancer patients in a tertiary care setting.
METHODS: The retrospective, cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, and comprised data of all patients diagnosed with breast cancer from March 2017 to December 2021. Demographic characteristics, clinical presentation, stage of the disease and histopathological characteristics were noted. Data related to all the variables was not available in all cases. Data was analysed using SPSS 23.
RESULTS: Of the 690 patients, 683(99%) were females and 7(1%) were males. The mean age at presentation was 49.3±13.5 years, while the mean duration of symptoms was 10.24±17.64) months. Most of the females were married 642(93%) and multiparous 484(70.9%), while 293(42.5%) had breastfed their children for >1 year, and 412(59.7%) had no history of contraception use. The most common stage at presentation was stage II (48.6%), and most patients had grade II 395(57.2%) invasive ductal carcinoma, with Luminal A molecular subtype noted in 287(41.6%) cases.
CONCLUSIONS: The characteristics of breast cancer in the sample had certain distinctions compared to other populations. It is important to integrate all datasets and develop guidelines appropriate to Pakistani population.
METHODS: The retrospective, cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, and comprised data of all patients diagnosed with breast cancer from March 2017 to December 2021. Demographic characteristics, clinical presentation, stage of the disease and histopathological characteristics were noted. Data related to all the variables was not available in all cases. Data was analysed using SPSS 23.
RESULTS: Of the 690 patients, 683(99%) were females and 7(1%) were males. The mean age at presentation was 49.3±13.5 years, while the mean duration of symptoms was 10.24±17.64) months. Most of the females were married 642(93%) and multiparous 484(70.9%), while 293(42.5%) had breastfed their children for >1 year, and 412(59.7%) had no history of contraception use. The most common stage at presentation was stage II (48.6%), and most patients had grade II 395(57.2%) invasive ductal carcinoma, with Luminal A molecular subtype noted in 287(41.6%) cases.
CONCLUSIONS: The characteristics of breast cancer in the sample had certain distinctions compared to other populations. It is important to integrate all datasets and develop guidelines appropriate to Pakistani population.
摘要：
目的：确定三级护理机构中乳腺癌患者的特征和危险因素。
方法：回顾性研究，横断面研究是在信德省泌尿外科和移植研究所进行的，卡拉奇,并包含2017年3月至2021年12月诊断为乳腺癌的所有患者的数据。人口特征，临床表现,注意到疾病的阶段和组织病理学特征。与所有变量相关的数据并非在所有情况下都可用。数据采用SPSS23进行分析。
结果：在690名患者中，683（99％）为女性，7（1％）为男性。演示时的平均年龄为49.3±13.5岁，而症状的平均持续时间为10.24±17.64）个月。大多数女性已婚642（93％）和多胎484（70.9％），而293（42.5%）母乳喂养孩子>1年，412例(59.7%)无避孕史.最常见的陈述阶段是第二阶段(48.6%),大多数患者患有II级395（57.2％）浸润性导管癌，在287例（41.6％）病例中注意到腔A分子亚型。
结论：与其他人群相比，样本中乳腺癌的特征有一定的差异。重要的是整合所有数据集并制定适合巴基斯坦人口的指南。
方法：回顾性研究，横断面研究是在信德省泌尿外科和移植研究所进行的，卡拉奇,并包含2017年3月至2021年12月诊断为乳腺癌的所有患者的数据。人口特征，临床表现,注意到疾病的阶段和组织病理学特征。与所有变量相关的数据并非在所有情况下都可用。数据采用SPSS23进行分析。
结果：在690名患者中，683（99％）为女性，7（1％）为男性。演示时的平均年龄为49.3±13.5岁，而症状的平均持续时间为10.24±17.64）个月。大多数女性已婚642（93％）和多胎484（70.9％），而293（42.5%）母乳喂养孩子>1年，412例(59.7%)无避孕史.最常见的陈述阶段是第二阶段(48.6%),大多数患者患有II级395（57.2％）浸润性导管癌，在287例（41.6％）病例中注意到腔A分子亚型。
结论：与其他人群相比，样本中乳腺癌的特征有一定的差异。重要的是整合所有数据集并制定适合巴基斯坦人口的指南。
