Abstract：
Gelatin and hydroxyapatite were assembled into polylactide porous matrix to prepare multicomponent porous composites for bone repair (PLA-gH). PLA-gH possessed a superior ability of mineralization. During simulated body fluids (SBF), the spherical Ca-P depositions on surface of PLA-gH became bulk as Ca/P decreased, while they locally turned into the rod with different variation in Ca/P during SBF containing bovine serum albumin (SBF-BSA), indicating that the mineralization of PLA-gH could be regulated by BSA. Meanwhile, PLA-gH possessed good degradation behaviour, especially in SBF-BSA, the degradation of PLA porous matrix was higher than that in SBF after 14-day immersion, whose crystallinity (Xc) decreased to a slightly lower level. Gelatin and hydroxyapatite endowed PLA-gH with good osteogenic property, characterized by obvious osteogenic differentiation and bone regeneration. In terms of predicting the cytocompatibility, osteogenic differentiation and new bone mineralization of PLA-gH by in vitro methods, applying SBF-BSA may be more reliable than SBF.
摘要：
将明胶和羟基磷灰石组装到聚乳酸多孔基质中，以制备用于骨修复的多组分多孔复合材料（PLA-gH）。PLA-gH具有优越的成矿能力。在模拟体液(SBF)期间，随着Ca/P的减少，PLA-gH表面的球形Ca-P沉积变为块状，在含有牛血清白蛋白（SBF-BSA）的SBF过程中，它们局部变成Ca/P变化不同的棒，表明PLA-gH的矿化可能受BSA的调控。同时,PLA-gH具有良好的降解行为，特别是在SBF-BSA中，浸泡14天后，PLA多孔基质的降解高于SBF，其结晶度(Xc)下降到略低的水平。明胶和羟基磷灰石赋予PLA-gH良好的成骨性能,具有明显的成骨分化和骨再生。在预测细胞相容性方面，通过体外方法研究PLA-gH的成骨分化和新骨矿化，应用SBF-BSA可能比SBF更可靠。
