OBJECTIVE: We aimed to analyze body composition in an Egyptian pediatric SCD cohort using dual-energy x-ray absorptiometry (DEXA), one of the most comprehensive and noninvasive assessment methods available.
METHODS: Forty children with SCD ≤18 years and 40 healthy youngsters age- and gender-matched were enrolled. Patients\' demographic, clinical, and laboratory parameters were obtained from their archived files. All patients and controls were subjected to body composition assessment using a MedixDR-Whole Body DEXA System.
RESULTS: In SCD patients; weight and height relative to age Z scores were significantly lower (p < .001), total body lean was significantly higher (p = .006), and total body fat percentage was lower, yet the difference was not statistically significant (p = .09). There were no statistically significant variations in bone mineral density or content, basal metabolic rate, subcutaneous adipose tissue, android/gynoid fat ratio, and visceral adipose tissue. There were no significant gender disparities between SCD patients and controls.
CONCLUSIONS: Faltering growth in children with SCD should be addressed with a multidisciplinary approach including nutritional support, correction of anemia, and proper medical care. Body composition parameters assessed using DEXA were comparable between cases and controls apart from total body lean. Further clinical studies are needed with multicenter cooperation and a larger sample size to assess the usefulness of DEXA as an assessment tool for body composition in children with SCD.
目的:我们的目的是使用双能X射线吸收法(DEXA)分析埃及儿科SCD队列中的身体成分,最全面和无创的评估方法之一。
方法:纳入40名SCD≤18岁儿童和40名年龄和性别相匹配的健康青少年。患者人口统计,临床,和实验室参数是从他们的存档文件中获得的。使用MedixDR-全身DEXA系统对所有患者和对照进行身体组成评估。
结果:在SCD患者中,体重和身高相对于年龄Z评分明显较低(p<.001),全身瘦肉明显更高(p=.006),全身脂肪百分比较低,但差异无统计学意义(p=.09).骨矿物质密度或含量没有统计学上的显着变化,基础代谢率,皮下脂肪组织,android/gynoid脂肪比率,和内脏脂肪组织.SCD患者和对照组之间没有明显的性别差异。
结论:应采用多学科方法,包括营养支持,来解决SCD儿童的生长迟缓问题。纠正贫血,和适当的医疗护理。使用DEXA评估的身体组成参数在病例和对照组之间具有可比性,而不是全身瘦。需要进行多中心合作和更大样本量的进一步临床研究,以评估DEXA作为SCD儿童身体成分评估工具的有用性。