PDF(Pubmed)
Abstract：
The descending-pain modulating circuit controls the experience of pain by modulating transmission of sensory signals through the dorsal horn. This circuit\'s key output node, the rostral ventromedial medulla (RVM), integrates \'top-down\' and \'bottom-up\' inputs that regulate functionally defined RVM cell types, \'OFF-cells\' and \'ON-cells\', which respectively suppress or facilitate pain-related sensory processing. While recent advances have sought molecular definition of RVM cell types, conflicting behavioral findings highlight challenges involved in aligning functional and molecularly defined types. This review summarizes current understanding, derived primarily from rodent studies but with corroborating evidence from human imaging, of the role of RVM populations in pain modulation and persistent pain states and explores recent advances outlining inputs to, and outputs from, RVM pain-modulating neurons.
摘要：
下降疼痛调节电路通过调节通过背角的感觉信号的传输来控制疼痛的体验。此电路的密钥输出节点，延髓头端腹内侧（RVM），集成了\'自上而下\'和\'自下而上\'输入，用于调节功能定义的RVM单元类型，\'OFF-cells\'和\'ON-cells\',分别抑制或促进疼痛相关的感觉处理。虽然最近的进展已经寻求RVM细胞类型的分子定义，相互矛盾的行为发现凸显了功能和分子定义类型对齐所涉及的挑战.这篇综述总结了目前的理解，主要来自啮齿动物研究，但有来自人体成像的确凿证据，RVM人群在疼痛调节和持续疼痛状态中的作用，并探讨了最近的进展，概述了输入，和输出，RVM痛觉调节神经元。
