关键词: Chronic Subdural Hematoma Diagnosis Drug treatment Pathogenic Mechanisms Review Surgical treatment

Mesh : Humans Hematoma, Subdural, Chronic / surgery therapy diagnosis Recurrence Neurosurgical Procedures / methods

来  源:   DOI:10.1016/j.clineuro.2024.108323

Abstract:
Chronic Subdural Hematoma (CSDH) is a common hemorrhagic disease in neurosurgery, and with the intensification of global aging, its incidence is gradually increasing. With the advancement of scientific technology, the etiological concepts and surgical treatments for CSDH have continually evolved over time. Currently, neuroscientists\' understanding of CSDH is no longer confined to bridging vein rupture; exploration of various mechanisms such as angiogenesis, maturation of blood vessels, and inflammation is also underway. In-depth exploration and discovery of pathogenic mechanisms guide the updating of clinical treatment strategies and methods. For different types of CSDH, there is now a clear guidance for the targeted selection of treatment methods. However, the current treatment of CSDH cannot completely solve all problems, and the updating of treatment methods as well as the development and validation of new effective drugs remain challenges for the future. In addition, the recurrence of CSDH is a significant issue that needs to be addressed. Although we have reviewed potential recurrent factors that may be associated, the strength of this evidence is insufficient. Future research should gradually focus on validating these recurrent factors and exploring new ones, in order to optimize the existing understanding and treatment of CSDH.
摘要:
慢性硬膜下血肿(CSDH)是神经外科常见的出血性疾病。随着全球老龄化的加剧,其发病率逐渐增加。随着科学技术的进步,CSDH的病因学概念和外科治疗随着时间的推移不断发展。目前,神经科学家对CSDH的理解不再局限于桥接静脉破裂;探索各种机制,如血管生成,血管的成熟,炎症也在进行中。对致病机制的深入探索和发现指导临床治疗策略和方法的更新。对于不同类型的CSDH,现在有明确的指导有针对性地选择治疗方法。然而,CSDH目前的治疗不能完全解决所有问题,治疗方法的更新以及新的有效药物的开发和验证仍然是未来的挑战。此外,CSDH的复发是一个需要解决的重大问题。虽然我们已经回顾了可能相关的潜在复发因素,这个证据的力量是不够的。未来的研究应该逐渐集中在验证这些复发因素并探索新的因素上,以优化现有对CSDH的认识和处理。
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