Abstract：
UNASSIGNED: Progestin-primed ovarian stimulation (PPOS) is an efficient controlled ovarian stimulation (COS) method. The study explored the pregnancy outcomes between PPOS and antagonist ovarian stimulation protocol (GnRH-ant) in infertile patients with poor ovarian response (POR).
UNASSIGNED: This retrospective study included patients with POR who underwent COS at the Reproductive Medical Center of Shanxi Maternal and Child Health Hospital from January 2021 to April 2022. The cycles were grouped as the GnRH-ant group and the PPOS group. The primary outcome was the clinical pregnancy rate; the secondary outcomes included the biochemical pregnancy abortion rate and live birth rate.
UNASSIGNED: Frozen embryo transfer was used in all cycles in this study. The cycles were divided into the GnRH-ant (n = 236 cycles) and PPOS (n = 273 cycles) groups. Age, BMI, type of infertility, infertility duration, FSH, LH, PRL, E2, T, P, and the number of cycles in the hospital were similar between the two groups (all p > 0.05). No statistically significant differences were observed in the clinical pregnancy rate (primary outcome, 32.71% vs. 43.90%, p = 0.082), total Gn dose, total Gn days, ART mode (IVF or ICSI), AFC, MII follicles, 2PN embryos, fertility, cycle cancelation rate, biochemical pregnancy rate, abortion rate, or live birth rate between the two groups (all p > 0.05). The PPOS group exhibited a higher rate of high-quality embryos than the GnRH-ant group (50.12% vs. 42.90%, p = 0.045).
UNASSIGNED: The PPOS protocol was comparable to the GnRH-ant protocol regarding induction parameters and cycle cancelation, biochemical pregnancy, clinical pregnancy, and abortion rates but might be associated with a higher proportion of high-quality embryos.
UNASSIGNED: This retrospective study included patients with POR who underwent COS at the Reproductive Medical Center of Shanxi Maternal and Child Health Hospital from January 2021 to April 2022. The cycles were grouped as the GnRH-ant group and the PPOS group. The primary outcome was the clinical pregnancy rate; the secondary outcomes included the biochemical pregnancy abortion rate and live birth rate.
UNASSIGNED: Frozen embryo transfer was used in all cycles in this study. The cycles were divided into the GnRH-ant (n = 236 cycles) and PPOS (n = 273 cycles) groups. Age, BMI, type of infertility, infertility duration, FSH, LH, PRL, E2, T, P, and the number of cycles in the hospital were similar between the two groups (all p > 0.05). No statistically significant differences were observed in the clinical pregnancy rate (primary outcome, 32.71% vs. 43.90%, p = 0.082), total Gn dose, total Gn days, ART mode (IVF or ICSI), AFC, MII follicles, 2PN embryos, fertility, cycle cancelation rate, biochemical pregnancy rate, abortion rate, or live birth rate between the two groups (all p > 0.05). The PPOS group exhibited a higher rate of high-quality embryos than the GnRH-ant group (50.12% vs. 42.90%, p = 0.045).
UNASSIGNED: The PPOS protocol was comparable to the GnRH-ant protocol regarding induction parameters and cycle cancelation, biochemical pregnancy, clinical pregnancy, and abortion rates but might be associated with a higher proportion of high-quality embryos.
摘要：
■孕激素引发的卵巢刺激（PPOS）是一种有效的控制性卵巢刺激（COS）方法。该研究探讨了PPOS和拮抗剂卵巢刺激方案（GnRH-ant）在卵巢反应不良（POR）的不孕患者中的妊娠结局。
■本回顾性研究纳入2021年1月至2022年4月在山西省妇幼保健院生殖医学中心行COS的POR患者。将这些周期分为GnRH-ant组和PPOS组。主要结局是临床妊娠率；次要结局包括生化妊娠流产率和活产率。
■在本研究的所有周期中都使用冷冻胚胎移植。周期分为GnRH-ant(n=236个周期)和PPOS(n=273个周期)组。年龄,BMI,不孕症的类型，不孕持续时间，FSH,LH,PRL,E2,T,P,两组的住院周期数相似（均p>0.05）。在临床妊娠率（主要结局，32.71%与43.90%,p=0.082),Gn总剂量,总Gn天，ART模式（IVF或ICSI），AFC,MII卵泡，2PN胚胎，生育力,周期取消率，生化妊娠率，流产率,两组之间的活产率（均p>0.05）。PPOS组的优质胚胎率高于GnRH-ant组（50.12％vs.42.90%,p=0.045)。
■在诱导参数和周期取消方面，PPOS方案与GnRH-ant方案相当，生化妊娠，临床妊娠,和流产率，但可能与更高比例的高质量胚胎有关。
■本回顾性研究纳入2021年1月至2022年4月在山西省妇幼保健院生殖医学中心行COS的POR患者。将这些周期分为GnRH-ant组和PPOS组。主要结局是临床妊娠率；次要结局包括生化妊娠流产率和活产率。
■在本研究的所有周期中都使用冷冻胚胎移植。周期分为GnRH-ant(n=236个周期)和PPOS(n=273个周期)组。年龄,BMI,不孕症的类型，不孕持续时间，FSH,LH,PRL,E2,T,P,两组的住院周期数相似（均p>0.05）。在临床妊娠率（主要结局，32.71%与43.90%,p=0.082),Gn总剂量,总Gn天，ART模式（IVF或ICSI），AFC,MII卵泡，2PN胚胎，生育力,周期取消率，生化妊娠率，流产率,两组之间的活产率（均p>0.05）。PPOS组的优质胚胎率高于GnRH-ant组（50.12％vs.42.90%,p=0.045)。
■在诱导参数和周期取消方面，PPOS方案与GnRH-ant方案相当，生化妊娠，临床妊娠,和流产率，但可能与更高比例的高质量胚胎有关。
