Abstract：
Increasing fruit and vegetable (FV) consumption is associated with reduced cardiovascular disease risk in observational studies but with little evidence from randomised controlled trials (RCTs). The impact of concurrent pharmacological therapy is unknown.
To pool data from six RCTs to examine the effect of increasing FV intake on blood pressure (BP) and lipid profile, also exploring whether effects differed by medication use.
Across trials, dietary intake was assessed by diet diaries or histories, lipids by routine biochemical methods and BP by automated monitors. Linear regression provided an estimate of the change in lipid profile or BP associated with a one portion increase in self-reported daily FV intake, with interaction terms fitted for medication use.
The pooled sample included a total of 554 participants (308 males and 246 females). Meta-analysis of regression coefficients revealed no significant change in either systolic or diastolic BP per portion FV increase, although there was significant heterogeneity across trials for systolic BP (I2 = 73%). Neither adjusting for change in body mass index, nor analysis according to use of anti-hypertensive medication altered the relationship. There was no significant change in lipid profile per portion FV increase, although there was a significant reduction in total cholesterol among those not on lipid-lowering therapy (P < 0.05 after Bonferroni correction).
Pooled analysis of six individual FV trials showed no impact of increasing intake on BP or lipids, but there was a total cholesterol-lowering effect in those not on lipid-lowering therapy.
To pool data from six RCTs to examine the effect of increasing FV intake on blood pressure (BP) and lipid profile, also exploring whether effects differed by medication use.
Across trials, dietary intake was assessed by diet diaries or histories, lipids by routine biochemical methods and BP by automated monitors. Linear regression provided an estimate of the change in lipid profile or BP associated with a one portion increase in self-reported daily FV intake, with interaction terms fitted for medication use.
The pooled sample included a total of 554 participants (308 males and 246 females). Meta-analysis of regression coefficients revealed no significant change in either systolic or diastolic BP per portion FV increase, although there was significant heterogeneity across trials for systolic BP (I2 = 73%). Neither adjusting for change in body mass index, nor analysis according to use of anti-hypertensive medication altered the relationship. There was no significant change in lipid profile per portion FV increase, although there was a significant reduction in total cholesterol among those not on lipid-lowering therapy (P < 0.05 after Bonferroni correction).
Pooled analysis of six individual FV trials showed no impact of increasing intake on BP or lipids, but there was a total cholesterol-lowering effect in those not on lipid-lowering therapy.
摘要：
背景：在观察性研究中，增加水果和蔬菜（FV）摄入量与降低心血管疾病风险相关，但随机对照试验（RCT）的证据很少。同步药物治疗的影响尚不清楚。
目的：汇集来自六个随机对照试验的数据，以检查增加FV摄入量对血压（BP）和血脂的影响，还探讨了药物使用的影响是否不同。
方法：所有试验，通过饮食日记或历史评估饮食摄入量，常规生化方法的脂质和自动监测仪的血压。线性回归提供了与自我报告的每日FV摄入量增加一部分相关的脂质分布或BP变化的估计，具有适合药物使用的相互作用术语。
结果：合并样本共包括554名参与者（308名男性和246名女性）。回归系数的荟萃分析显示，每部分FV增加的收缩压或舒张压均无明显变化，尽管在所有试验中收缩压存在显著异质性(I2=73%).既不调整体重指数的变化，根据使用抗高血压药物的分析也没有改变这种关系。每个FV增加部分的脂质分布没有显著变化，尽管未接受降脂治疗的患者中总胆固醇显着降低（Bonferroni校正后P<0.05）。
结论：六项FV试验的汇总分析显示，增加摄入对血压或血脂没有影响，但那些不接受降脂治疗的患者有降低总胆固醇的作用。
目的：汇集来自六个随机对照试验的数据，以检查增加FV摄入量对血压（BP）和血脂的影响，还探讨了药物使用的影响是否不同。
方法：所有试验，通过饮食日记或历史评估饮食摄入量，常规生化方法的脂质和自动监测仪的血压。线性回归提供了与自我报告的每日FV摄入量增加一部分相关的脂质分布或BP变化的估计，具有适合药物使用的相互作用术语。
结果：合并样本共包括554名参与者（308名男性和246名女性）。回归系数的荟萃分析显示，每部分FV增加的收缩压或舒张压均无明显变化，尽管在所有试验中收缩压存在显著异质性(I2=73%).既不调整体重指数的变化，根据使用抗高血压药物的分析也没有改变这种关系。每个FV增加部分的脂质分布没有显著变化，尽管未接受降脂治疗的患者中总胆固醇显着降低（Bonferroni校正后P<0.05）。
结论：六项FV试验的汇总分析显示，增加摄入对血压或血脂没有影响，但那些不接受降脂治疗的患者有降低总胆固醇的作用。
