Abstract：
Breast cancer presents a significant global health challenge, ranking highest incidence rate among all types of cancers. Functionalised nanocarriers offer a promising solution for precise drug delivery by actively targeting cancer cells through specific receptors, notably folate receptors. By overcoming the limitations of passive targeting in conventional therapies, this approach holds the potential for enhanced treatment efficacy through combination therapy. Encouraging outcomes from studies like in vitro and in vivo, underscore the promise of this innovative approach. This review explores the therapeutic potential of FA (Folic acid) functionalised nanocarriers tailored for breast cancer management, discussing various chemical modification techniques for functionalization. It examines FA-conjugated nanocarriers containing chemotherapeutics to enhance treatment efficacy and addresses the pharmacokinetic aspect of these functionalised nanocarriers. Additionally, the review integrates active targeting via folic acid with theranostics, photothermal therapy, and photodynamic therapy, offering a comprehensive management strategy. Emphasising rigorous experimental validation for practical utility, the review underscores the need to bridge laboratory research to clinical application. While these functionalised nanocarriers show promise, their credibility and applicability in real-world settings necessitate thorough validation for effective clinical use.
摘要：
乳腺癌是一个重大的全球健康挑战，在所有类型的癌症中发病率最高。功能化纳米载体通过特异性受体主动靶向癌细胞，为精确药物递送提供了有希望的解决方案，特别是叶酸受体。通过克服传统疗法中被动靶向的局限性，这种方法具有通过联合治疗提高治疗疗效的潜力.来自体外和体内研究的令人鼓舞的结果，强调这种创新方法的前景。这篇综述探讨了为乳腺癌管理量身定制的FA（叶酸）功能化纳米载体的治疗潜力，讨论各种功能化的化学改性技术。它研究了含有化疗剂的FA缀合的纳米载体，以增强治疗功效，并解决了这些官能化纳米载体的药代动力学方面。此外,该综述将通过叶酸的主动靶向与疗法相结合，光热疗法,光动力疗法,提供全面的管理策略。强调对实际效用的严格实验验证，这篇综述强调了将实验室研究与临床应用联系起来的必要性。虽然这些功能化的纳米载体显示出希望，它们在现实环境中的可信度和适用性需要对有效的临床应用进行彻底验证.
