PDF(Pubmed)
Abstract：
PET/MRI is a hybrid imaging modality that boasts the simultaneous acquisition of high-resolution anatomical data and metabolic information. Having these exceptional capabilities, it is often implicated in clinical research for diagnosing and grading, as well as tracking disease progression and response to interventions. Despite this, its low level of clinical widespread use is questioned. This is especially the case with Parkinson\'s disease (PD), the fastest progressively disabling and neurodegenerative cause of death. To optimise the clinical applicability of PET/MRI for diagnosing, differentiating, and tracking PD progression, the emerging novel uses, and current challenges must be identified. This systematic review aimed to present the specific challenges of PET/MRI use in PD. Further, this review aimed to highlight the possible resolution of these challenges, the emerging applications and future direction of PET/MRI use in PD. EBSCOHost (indexing CINAHL Plus, PsycINFO) Ovid (Medline, EMBASE) PubMed, Web of Science, and Scopus from 2006 (the year of first integrated PET/MRI hybrid system) to 30 September 2022 were used to search for relevant primary articles. A total of 933 studies were retrieved and following the screening procedure, 18 peer-reviewed articles were included in this review. This present study is of great clinical relevance and significance, as it informs the reasoning behind hindered widespread clinical use of PET/MRI for PD. Despite this, the emerging applications of image reconstruction developed by PET/MRI research data to the use of fully automated systems show promising and desirable utility. Furthermore, many of the current challenges and limitations can be resolved by using much larger-sampled and longitudinal studies. Meanwhile, the development of new fast-binding tracers that have specific affinity to PD pathological processes is warranted.
摘要：
PET/MRI是一种混合成像模式，可同时采集高分辨率解剖数据和代谢信息。有了这些非凡的能力，它通常涉及诊断和分级的临床研究，以及跟踪疾病进展和对干预措施的反应。尽管如此,其低水平的临床广泛使用受到质疑。帕金森病（PD）尤其如此，最快的逐渐致残和神经退行性死亡原因。为了优化PET/MRI诊断的临床适用性，差异化,追踪PD进展,新兴的小说用途，必须确定当前的挑战。本系统综述旨在介绍PET/MRI在PD中使用的具体挑战。Further,这次审查旨在强调这些挑战的可能解决，PET/MRI在PD中的新兴应用和未来应用方向。EBSCOHost(indexingCINAHLPlus，PsycINFO）奥维德（Medline，EMBASE)PubMed,WebofScience,和从2006年(首次集成PET/MRI混合系统的年份)到2022年9月30日的Scopus被用于搜索相关的主要文章。共检索了933项研究，并遵循筛查程序，本综述包括18篇同行评审的文章。本研究具有重要的临床意义,因为它说明了阻碍PET/MRI在临床上广泛使用PD的原因。尽管如此,由PET/MRI研究数据开发的图像重建的新兴应用到使用全自动系统显示出有希望和理想的实用性。此外，当前的许多挑战和限制可以通过使用更大的样本和纵向研究来解决。同时,有必要开发新的对PD病理过程具有特异性亲和力的快速结合示踪剂.
