Abstract：
BACKGROUND: Dry eye is a condition related to long-term topical eye therapy. We wish to evaluate the effectiveness and tolerability of preservative free prostaglandin drops versus benzalkonium chloride containing prostaglandin drops in the treatment of glaucoma.
METHODS: Patients undergoing prostaglandin monotherapy underwent a washout period of at least 1 month after which baseline measurements of dry eye severity were taken. Patients were randomised to receive either 0.0015% tafluprost drops or 0.005% latanoprost preserved with 0.02% benzalkonium chloride. Repeat measurements were taken after a 2-month interval.
RESULTS: Thirty-five patients completed randomised treatment. No significant difference between groups was found in objective and subjective measurements of dry eye severity. No significant difference was found in measurement of treatment effectiveness.
CONCLUSIONS: Preservative-free and benzalkonium chloride-containing drops were found to be equally effective in lowering IOP with no significant difference in either subjective or objective measurements of dry eye severity.
METHODS: Patients undergoing prostaglandin monotherapy underwent a washout period of at least 1 month after which baseline measurements of dry eye severity were taken. Patients were randomised to receive either 0.0015% tafluprost drops or 0.005% latanoprost preserved with 0.02% benzalkonium chloride. Repeat measurements were taken after a 2-month interval.
RESULTS: Thirty-five patients completed randomised treatment. No significant difference between groups was found in objective and subjective measurements of dry eye severity. No significant difference was found in measurement of treatment effectiveness.
CONCLUSIONS: Preservative-free and benzalkonium chloride-containing drops were found to be equally effective in lowering IOP with no significant difference in either subjective or objective measurements of dry eye severity.
摘要：
背景：干眼症是与长期局部眼部治疗相关的病症。我们希望评估不含防腐剂的前列腺素滴剂与含苯扎氯铵的前列腺素滴剂治疗青光眼的有效性和耐受性。
方法：接受前列腺素单药治疗的患者接受至少1个月的冲洗期，之后进行干眼严重程度的基线测量。患者被随机分配接受0.0015％他氟前列素滴剂或用0.02％苯扎氯铵保存的0.005％拉坦前列素滴剂。间隔2个月后进行重复测量。
结果：35例患者完成随机治疗。在干眼严重程度的客观和主观测量中，组间没有发现显着差异。在治疗有效性的测量中没有发现显着差异。
结论：发现不含防腐剂的滴剂和含苯扎氯铵的滴剂在降低眼压方面同样有效，在干眼严重程度的主观或客观测量中没有显着差异。
方法：接受前列腺素单药治疗的患者接受至少1个月的冲洗期，之后进行干眼严重程度的基线测量。患者被随机分配接受0.0015％他氟前列素滴剂或用0.02％苯扎氯铵保存的0.005％拉坦前列素滴剂。间隔2个月后进行重复测量。
结果：35例患者完成随机治疗。在干眼严重程度的客观和主观测量中，组间没有发现显着差异。在治疗有效性的测量中没有发现显着差异。
结论：发现不含防腐剂的滴剂和含苯扎氯铵的滴剂在降低眼压方面同样有效，在干眼严重程度的主观或客观测量中没有显着差异。
