Abstract：
Climate change-induced alterations in temperature variation, ozone exposure, water salinity and acidification, and hypoxia might influence immunity and thus survival in diverse groups of animals from fish to mammals. Pyroptosis is a type of lytic pro-inflammatory programmed cell death, which participates in the innate immune response, and is involved in multiple diseases characterized by inflammation and cell death, mostly studied in human cells. Diverse extrinsic factors can induce pyroptosis, leading to the extracellular release of pro-inflammatory molecules such as IL-18. Climate change-related factors, either directly or indirectly, can also promote animal cell death via different regulated mechanisms, impacting organismal fitness. However, pyroptosis has been relatively less studied in this context compared to another cell death process, apoptosis. This review covers previous research pointing to the potential impact of climate change, through various abiotic stressors, on pyroptotic cell death in different animal cells in various contexts. It was proposed that temperature, ozone exposure, water salinity, water acidification and hypoxia have the potential to induce pyroptotic cell death in animal cells and promote inflammation, and that these pyroptotic events should be better understood to be able to mitigate the adverse effects of climate change on animal physiology and health. This is of high importance considering the increasing frequency, intensity and duration of climate-based changes in these environmental parameters, and the critical function of pyroptosis in immune responses of animals and in their predisposition to multiple diseases including cancer. Furthermore, the need for further mechanistic studies showing the more direct impact of climate change-induced environmental alterations on pyroptotic cell death in animals at the organismal level was highlighted. A complete picture of the association between climate change and pyroptosis in animals will be also highly valuable in terms of ecological and clinical applications, and it requires an interdisciplinary approach. SIGNIFICANCE: Climate change-induced alterations might influence animal physiology. Pyroptosis is a form of cell death with pro-inflammatory characteristics. Previous research suggests that temperature variation, ozone exposure, water salinity and acidification, and hypoxia might have the potential to contribute to pyroptotic cell death in certain cell types and contexts. Climate change-induced pyroptotic cell death should be better understood to be able to mitigate the adverse effects of climate change on animal health.
摘要：
气候变化引起的温度变化变化，臭氧暴露,水的盐度和酸化，缺氧可能会影响免疫力，从而影响从鱼类到哺乳动物的各种动物群体的生存。发热是一种裂解性促炎性程序性细胞死亡，参与先天免疫反应，并参与以炎症和细胞死亡为特征的多种疾病，主要在人类细胞中研究。不同的外在因素可以诱导焦亡，导致促炎分子如IL-18的细胞外释放。气候变化相关因素，直接或间接,还可以通过不同的调节机制促进动物细胞死亡，影响机体健康。然而,与另一种细胞死亡过程相比，在这种情况下对焦亡的研究相对较少，凋亡。这篇综述涵盖了以前的研究，指出气候变化的潜在影响，通过各种非生物压力，在不同情况下不同动物细胞的焦转细胞死亡。有人提出温度，臭氧暴露,水的盐度,水酸化和缺氧有可能诱导动物细胞中的细胞凋亡并促进炎症，并且应该更好地理解这些退化事件，以便能够减轻气候变化对动物生理和健康的不利影响。考虑到频率的增加，这是非常重要的，这些环境参数中基于气候的变化的强度和持续时间，以及焦亡在动物免疫反应中的关键功能，以及它们对包括癌症在内的多种疾病的易感性。此外，强调了需要进一步的机制研究，表明气候变化引起的环境变化对生物体水平的动物的焦化性细胞死亡的更直接影响。在生态和临床应用方面，全面了解气候变化与动物的热死亡之间的关系也将非常有价值。这需要跨学科的方法。意义：气候变化引起的改变可能会影响动物生理学。焦亡是一种具有促炎特征的细胞死亡形式。先前的研究表明，温度变化，臭氧暴露,水的盐度和酸化，在某些细胞类型和环境中，缺氧可能会导致细胞凋亡。应更好地理解气候变化引起的细胞凋亡，以减轻气候变化对动物健康的不利影响。
