Abstract：
Intensive Care Unit-acquired weakness (ICU-AW) is a common complication that significantly impedes patient recovery. In the study, we investigated the correlation between early serum myoglobin levels in patients with septic shock due to pneumonia, and the incidence of ICU-AW, duration of mechanical ventilation, and prognosis. Patients were classified based on the development of ICU-AW within the first 10 days of ICU admission. We measured serum myoglobin levels upon ICU entry, and analyzed demographic data, APACHE II scores, use of mechanical ventilation, and clinical outcomes, including mortality and duration of mechanical ventilation. The results indicated significantly elevated serum myoglobin levels in the ICU-AW group, correlated with prolonged mechanical ventilation and increased mortality. ROC analysis revealed myoglobin as a promising biomarker for predicting ICU-AW, with an area under the curve of 0.843 (95% CI: 0.819~0.867), demonstrating a sensitivity of 76.00% and specificity of 82.30%. These findings underscored serum myoglobin as a predictive biomarker for early ICU-AW in septic shock patients, highlighting its potential to guide clinical decision-making.
摘要：
重症监护病房获得性虚弱（ICU-AW）是一种常见的并发症，严重阻碍了患者的康复。在研究中,我们调查了肺炎引起的脓毒性休克患者早期血清肌红蛋白水平之间的相关性，和ICU-AW的发病率，机械通气的持续时间，和预后。根据入住ICU的前10天内ICU-AW的发展对患者进行分类。我们在进入ICU时测量了血清肌红蛋白水平，并分析了人口统计数据，APACHEII得分,使用机械通气，和临床结果，包括死亡率和机械通气的持续时间。结果表明，ICU-AW组的血清肌红蛋白水平显着升高，与机械通气时间延长和死亡率增加相关。ROC分析显示肌红蛋白是预测ICU-AW的有希望的生物标志物，曲线下面积为0.843(95%CI:0.819~0.867),敏感性为76.00%，特异性为82.30%。这些发现强调了血清肌红蛋白作为感染性休克患者早期ICU-AW的预测生物标志物，强调其指导临床决策的潜力。
