Abstract：
BACKGROUND: Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
OBJECTIVE: To investigate brain networks associated with anxiety in CD.
METHODS: Twenty-six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State-Trait Anxiety Inventory (STAI) state (STAI-S) and trait (STAI-T) subscales.
RESULTS: Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
CONCLUSIONS: Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.
OBJECTIVE: To investigate brain networks associated with anxiety in CD.
METHODS: Twenty-six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State-Trait Anxiety Inventory (STAI) state (STAI-S) and trait (STAI-T) subscales.
RESULTS: Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
CONCLUSIONS: Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.
摘要：
背景：焦虑可能先于宫颈肌张力障碍（CD）的运动症状，并且与肌张力障碍的早期发作有关。我们对CD中的焦虑的理解是不够的。
目的：研究与CD焦虑相关的脑网络。
方法：26例特发性CD患者接受MRI头颅检查，无造影。相关纤维束造影是使用扩散MRI连接计得出的。定量各向异性（QA）用于确定性扩散纤维示踪。然后使用相关示踪图将QA与状态-特质焦虑量表（STAI）状态（STAI-S）和特征（STAI-T）分量表相关联。
结果：Connectometry分析显示，从杏仁核到双侧丘脑/脉搏束的状态焦虑与QA之间存在直接相关性，从杏仁核到运动皮层的特质焦虑和QA，双侧感觉运动皮质和顶叶关联区（FDR≤0.05）。
结论：我们将焦虑映射到CD中的大脑网络的努力强调了杏仁核在CD中焦虑的病理生理学中的作用。
目的：研究与CD焦虑相关的脑网络。
方法：26例特发性CD患者接受MRI头颅检查，无造影。相关纤维束造影是使用扩散MRI连接计得出的。定量各向异性（QA）用于确定性扩散纤维示踪。然后使用相关示踪图将QA与状态-特质焦虑量表（STAI）状态（STAI-S）和特征（STAI-T）分量表相关联。
结果：Connectometry分析显示，从杏仁核到双侧丘脑/脉搏束的状态焦虑与QA之间存在直接相关性，从杏仁核到运动皮层的特质焦虑和QA，双侧感觉运动皮质和顶叶关联区（FDR≤0.05）。
结论：我们将焦虑映射到CD中的大脑网络的努力强调了杏仁核在CD中焦虑的病理生理学中的作用。
