Abstract：
The bio-reductive fabrication of nanomaterials is a developing arena of study that seeks to fabricate nanoparticles (NPs) using microorganisms, plants, and animal blood. However, the chemical approach of AgNPs fulfills the need of abundant need of NPs. In contrast, chemically fabricated AgNPs are more toxic than biological AgNPs. Therefore, the current study aimed to assess and evaluate the chemically fabricated silver nanoparticles (AgNPs) for their possible toxicity in Common carp fish (Cyprinus carpio). The chemically synthesized silver nanoparticles were purchased from the market and applied for their possible toxicity. The chemically fabricated AgNPs were used against the Cyprinus carpio for bioaccumulation in different organs and histological alterations in the intestine and muscles. The results revealed that the AgNPs were mostly accumulated in the intestines followed by the gills, liver, and muscles (p < .05). The accumulated AgNPs caused histological alterations in gills and intestines at the highest concentration (0.08 mg/L). However, no alterations were observed by the middle and lowest concentration of AgNPs, particularly, in the intestine. In conclusion, more extensive research is required to establish the hazards related to the use of nanoparticles to disclose their negative effects on fish and the aquatic environment. REASEARCH HIGHLIGHTS: The chemical method fabricates a large amount of AgNPs Additionally, considered more toxic than the bio-reductive method AgNPs have excellent and diverse applications AgNPs deposited in various organs and cause histological changes.
摘要：
纳米材料的生物还原制造是一个发展中的研究领域，旨在使用微生物制造纳米颗粒（NPs），植物,动物血然而,AgNPs的化学方法满足了对NPs的大量需求。相比之下,化学制造的AgNPs比生物AgNPs毒性更大。因此,本研究旨在评估和评估化学制造的银纳米颗粒（AgNPs）对鲤鱼（Cyprinuscarpio）的可能毒性。化学合成的银纳米颗粒从市场上购买并应用于其可能的毒性。化学制造的AgNP用于对抗鲤鱼，用于在不同器官中的生物积累以及肠和肌肉中的组织学改变。结果表明，AgNPs主要在肠道中积累，其次是g，肝脏,和肌肉（p<0.05）。在最高浓度（0.08mg/L）时，积累的AgNPs会引起g和肠的组织学改变。然而,AgNPs的中间和最低浓度没有观察到改变，特别是,在肠道里.总之,需要更广泛的研究来确定与使用纳米颗粒有关的危害，以揭示它们对鱼类和水生环境的负面影响。研究重点：化学方法制造了大量的AgNPs。被认为比生物还原方法更具毒性的AgNPs具有优异和多样化的应用AgNPs沉积在各种器官中并引起组织学变化。
