PDF(Pubmed)
Abstract：
UNASSIGNED: Increasing evidence indicates that gut microbiota dysbiosis is related to synovitis and tenosynovitis. Nonetheless, whether these associations are causal is currently unknown.
UNASSIGNED: A two-sample Mendelian randomization (MR) study was performed to reveal the causality of gut microbiota with synovitis and tenosynovitis.
UNASSIGNED: The summary statistical data from a large-scale genome-wide association study (GWAS) were applied as the basis for a two-sample MR analysis. The causal effect was estimated using inverse variance weighted (IVW), weighted median, simple mode, MR-Egger, and weighted mode methods, of which IVW was the important method. Meanwhile, the pleiotropy and heterogeneity were detected and measured using MR-Egger regression, Cochran\'s Q statistics, funnel plots, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.
UNASSIGNED: The IVW technique demonstrated that genetically predicted five genera, namely Gordonibacter [odds ratio (OR) = 0.999, 95% confidence interval (CI): (0.9977, 0.9998), p = 0.019], Paraprevotella [OR = 0.999, 95% CI: (0.9971, 0.9999), p = 0.036], Lachnoclostridium [OR = 0.998, 95% CI: (0.9954, 0.9999), p = 0.041], RuminococcaceaeUCG003 [OR = 0.997, 95% CI: (0.9955, 0.9994), p = 0.011], and FamilyXIIIAD3011group [OR = 0.997, 95% CI: (0.9954, 0.9992), p = 0.006] were negatively correlated with the risk of synovitis and tenosynovitis, while two other genera, namely Ruminococcustorquesgroup [OR = 1.003, 95% CI: (1.0004, 1.0049), p = 0.019] and Parabacteroides [OR = 1.003, 95% CI: (1.0002, 1.0052), p = 0.035] were positively associated with synovitis and tenosynovitis risk. In addition, the data of sensitivity analyses demonstrated that there were no outliers, horizontal pleiotropy, or heterogeneity in the causal relationship of the above-mentioned gut microbiota on synovitis and tenosynovitis (p > 0.05).
UNASSIGNED: The results of the study suggested that the gut microbiota was causally involved in synovitis and tenosynovitis and identified specific bacterial taxa that affect synovitis and tenosynovitis, which provide new insights into the pathogenesis underlying the development of synovitis and tenosynovitis mediated by gut microbiota.
UNASSIGNED: A two-sample Mendelian randomization (MR) study was performed to reveal the causality of gut microbiota with synovitis and tenosynovitis.
UNASSIGNED: The summary statistical data from a large-scale genome-wide association study (GWAS) were applied as the basis for a two-sample MR analysis. The causal effect was estimated using inverse variance weighted (IVW), weighted median, simple mode, MR-Egger, and weighted mode methods, of which IVW was the important method. Meanwhile, the pleiotropy and heterogeneity were detected and measured using MR-Egger regression, Cochran\'s Q statistics, funnel plots, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.
UNASSIGNED: The IVW technique demonstrated that genetically predicted five genera, namely Gordonibacter [odds ratio (OR) = 0.999, 95% confidence interval (CI): (0.9977, 0.9998), p = 0.019], Paraprevotella [OR = 0.999, 95% CI: (0.9971, 0.9999), p = 0.036], Lachnoclostridium [OR = 0.998, 95% CI: (0.9954, 0.9999), p = 0.041], RuminococcaceaeUCG003 [OR = 0.997, 95% CI: (0.9955, 0.9994), p = 0.011], and FamilyXIIIAD3011group [OR = 0.997, 95% CI: (0.9954, 0.9992), p = 0.006] were negatively correlated with the risk of synovitis and tenosynovitis, while two other genera, namely Ruminococcustorquesgroup [OR = 1.003, 95% CI: (1.0004, 1.0049), p = 0.019] and Parabacteroides [OR = 1.003, 95% CI: (1.0002, 1.0052), p = 0.035] were positively associated with synovitis and tenosynovitis risk. In addition, the data of sensitivity analyses demonstrated that there were no outliers, horizontal pleiotropy, or heterogeneity in the causal relationship of the above-mentioned gut microbiota on synovitis and tenosynovitis (p > 0.05).
UNASSIGNED: The results of the study suggested that the gut microbiota was causally involved in synovitis and tenosynovitis and identified specific bacterial taxa that affect synovitis and tenosynovitis, which provide new insights into the pathogenesis underlying the development of synovitis and tenosynovitis mediated by gut microbiota.
摘要：
■越来越多的证据表明肠道微生物群生态失调与滑膜炎和腱鞘炎有关。尽管如此，这些关联是否是因果关系目前尚不清楚.
■进行了双样本孟德尔随机化（MR）研究，以揭示肠道微生物群与滑膜炎和腱鞘炎的因果关系。
■来自大规模全基因组关联研究（GWAS）的汇总统计数据被用作双样本MR分析的基础。因果效应是使用逆方差加权(IVW)估计的，加权中位数，简单模式，MR-Egger,和加权模式方法，其中IVW是重要的方法。同时,使用MR-Egger回归检测和测量多效性和异质性，Cochran的Q统计数据，漏斗图,和MR多效性残差和离群值(MR-PRESSO)方法。
■IVW技术证明了遗传预测五个属，即Gordonibacter[优势比（OR）=0.999，95%置信区间（CI）：（0.9977，0.9998），p=0.019],Paraprevotella[OR=0.999，95%CI：（0.9971，0.9999），p=0.036],衣原体[OR=0.998，95%CI：（0.9954，0.9999），p=0.041],RuminoccaceaUCG003[OR=0.997，95%CI：（0.9955，0.9994），p=0.011],和FamilyXIIIAD3011组[OR=0.997，95%CI：（0.9954，0.9992），p=0.006]与滑膜炎和腱鞘炎的风险呈负相关，而另外两个属，即Ruminococstoquesgroup[OR=1.003，95%CI：（1.0004，1.0049），p=0.019]和副杆菌属[OR=1.003，95%CI：（1.0002，1.0052），p=0.035]与滑膜炎和腱鞘炎风险呈正相关。此外,敏感性分析的数据表明没有异常值，水平多效性，或上述肠道菌群对滑膜炎和腱鞘炎因果关系的异质性(p>0.05)。
■研究结果表明，肠道微生物群与滑膜炎和腱鞘炎有因果关系，并确定了影响滑膜炎和腱鞘炎的特定细菌类群，这为肠道微生物群介导的滑膜炎和腱鞘炎的发病机制提供了新的见解。
■进行了双样本孟德尔随机化（MR）研究，以揭示肠道微生物群与滑膜炎和腱鞘炎的因果关系。
■来自大规模全基因组关联研究（GWAS）的汇总统计数据被用作双样本MR分析的基础。因果效应是使用逆方差加权(IVW)估计的，加权中位数，简单模式，MR-Egger,和加权模式方法，其中IVW是重要的方法。同时,使用MR-Egger回归检测和测量多效性和异质性，Cochran的Q统计数据，漏斗图,和MR多效性残差和离群值(MR-PRESSO)方法。
■IVW技术证明了遗传预测五个属，即Gordonibacter[优势比（OR）=0.999，95%置信区间（CI）：（0.9977，0.9998），p=0.019],Paraprevotella[OR=0.999，95%CI：（0.9971，0.9999），p=0.036],衣原体[OR=0.998，95%CI：（0.9954，0.9999），p=0.041],RuminoccaceaUCG003[OR=0.997，95%CI：（0.9955，0.9994），p=0.011],和FamilyXIIIAD3011组[OR=0.997，95%CI：（0.9954，0.9992），p=0.006]与滑膜炎和腱鞘炎的风险呈负相关，而另外两个属，即Ruminococstoquesgroup[OR=1.003，95%CI：（1.0004，1.0049），p=0.019]和副杆菌属[OR=1.003，95%CI：（1.0002，1.0052），p=0.035]与滑膜炎和腱鞘炎风险呈正相关。此外,敏感性分析的数据表明没有异常值，水平多效性，或上述肠道菌群对滑膜炎和腱鞘炎因果关系的异质性(p>0.05)。
■研究结果表明，肠道微生物群与滑膜炎和腱鞘炎有因果关系，并确定了影响滑膜炎和腱鞘炎的特定细菌类群，这为肠道微生物群介导的滑膜炎和腱鞘炎的发病机制提供了新的见解。
