PDF(Pubmed)
Abstract：
UNASSIGNED: Sudden onset of olfactory dysfunction (OD) manifesting as hyposmia and/or anosmia occurred in many COVID-19 patients, with a frequency as high as 85.6%. Given the morbidity and mortality of COVID-19, it is important to recognize the symptoms early so that the infected person can be diagnosed, isolated and treated early. Hence, this study was undertaken to know the prevalence of Sino-nasal symptoms with special reference to olfactory dysfunction in COVID-19 patients.
UNASSIGNED: It is a cross sectional observational study involving 160 COVID-19 patients aged 18 to 100 years selected by universal sampling. OD was analyzed and compared with various inflammatory markers and Sino-nasal symptoms. Patients were followed up until their discharge from the hospital or until death due to COVID-19 related health issues.
UNASSIGNED: Out of 160 subjects included in the study, 61.88 % of the study participants were males and 38.13% were females. The mean age was 44.50 ± 16.43 years. A total of 51 patients (31.87%) developed OD. Fifty one (31.87%) patients developed OD (anosmia/hyposmia). Among the individuals with anosmia/hyposmia, majority of patients (n=26) (50.98%) complained of more than 75% loss of smell sensation. Mean duration of anosmia/hyposmia was 9.92 ± 3.71 days. OD correlated with serum ferritin levels (p=0.0453).
UNASSIGNED: Anosmia/hyposmia was found in significant proportion of patients with covid-19 which correlated with the disease severity and serum ferritin levels and hence can serve as surrogate marker of disease severity.
UNASSIGNED: It is a cross sectional observational study involving 160 COVID-19 patients aged 18 to 100 years selected by universal sampling. OD was analyzed and compared with various inflammatory markers and Sino-nasal symptoms. Patients were followed up until their discharge from the hospital or until death due to COVID-19 related health issues.
UNASSIGNED: Out of 160 subjects included in the study, 61.88 % of the study participants were males and 38.13% were females. The mean age was 44.50 ± 16.43 years. A total of 51 patients (31.87%) developed OD. Fifty one (31.87%) patients developed OD (anosmia/hyposmia). Among the individuals with anosmia/hyposmia, majority of patients (n=26) (50.98%) complained of more than 75% loss of smell sensation. Mean duration of anosmia/hyposmia was 9.92 ± 3.71 days. OD correlated with serum ferritin levels (p=0.0453).
UNASSIGNED: Anosmia/hyposmia was found in significant proportion of patients with covid-19 which correlated with the disease severity and serum ferritin levels and hence can serve as surrogate marker of disease severity.
摘要：
■许多COVID-19患者突然出现嗅觉功能障碍（OD），表现为嗅觉减退和/或嗅觉缺失，频率高达85.6%。鉴于COVID-19的发病率和死亡率，重要的是要及早识别症状，以便能够诊断感染者，早期隔离和治疗。因此，本研究旨在了解COVID-19患者鼻部症状的患病率,特别是嗅觉功能障碍.
■这是一项横断面观察性研究，涉及通过普遍抽样选择的160名18至100岁的COVID-19患者。对OD进行了分析，并与各种炎症标志物和鼻塞症状进行了比较。对患者进行随访，直到他们出院或因COVID-19相关健康问题死亡。
■在纳入研究的160名受试者中，61.88%的研究参与者是男性，38.13%是女性。平均年龄为44.50±16.43岁。共有51例患者（31.87％）出现OD。51例（31.87％）患者出现OD（嗅觉缺失/嗅觉减退）。在有嗅觉缺失/嗅觉减退的个体中，大多数患者（n=26）（50.98％）抱怨嗅觉丧失超过75％。失语症/失语症的平均持续时间为9.92±3.71天。OD与血清铁蛋白水平相关(p=0.0453)。
■在与疾病严重程度和血清铁蛋白水平相关的covid-19患者中发现了显著比例的失足/失足,因此可以作为疾病严重程度的替代标志物。
■这是一项横断面观察性研究，涉及通过普遍抽样选择的160名18至100岁的COVID-19患者。对OD进行了分析，并与各种炎症标志物和鼻塞症状进行了比较。对患者进行随访，直到他们出院或因COVID-19相关健康问题死亡。
■在纳入研究的160名受试者中，61.88%的研究参与者是男性，38.13%是女性。平均年龄为44.50±16.43岁。共有51例患者（31.87％）出现OD。51例（31.87％）患者出现OD（嗅觉缺失/嗅觉减退）。在有嗅觉缺失/嗅觉减退的个体中，大多数患者（n=26）（50.98％）抱怨嗅觉丧失超过75％。失语症/失语症的平均持续时间为9.92±3.71天。OD与血清铁蛋白水平相关(p=0.0453)。
■在与疾病严重程度和血清铁蛋白水平相关的covid-19患者中发现了显著比例的失足/失足,因此可以作为疾病严重程度的替代标志物。
