Abstract：
BACKGROUND: It is important to distinguish Waldenström macroglobulinemia from smoldering Waldenström macroglobulinemia (sWM), because only patients with Waldenström macroglobulinemia require treatment, however the distinction can be clinically complex. The aim of this study is to investigate whether [ 68 Ga]Ga-pentixafor PET/CT shows different characteristics in sWM and Waldenström macroglobulinemia patients and therefore can help to differentiate Waldenström macroglobulinemia and sWM.
RESULTS: Thirty-seven patients with newly diagnosed Waldenström macroglobulinemia and 11 sWM patients were analyzed [35 men and 13 women; 64.3 ± 10.7 (range, 29-87) years old]. The SUV max of bone marrow disease, lymph nodes, and other extramedullary diseases on [ 68 Ga]Ga-pentixafor were significantly higher than those on 2-[ 18 F]FDG PET/CT ( P < 0.05). On [ 68 Ga]Ga-pentixafor PET/CT, patients with Waldenström macroglobulinemia had more lymph node regions involved, significantly higher incidence of involvement in more than three lymph node regions, larger nodal disease, and higher incidence of other extramedullary disease when compared with sWM patients ( P < 0.05). Waldenström macroglobulinemia patients showed significantly higher total lesions uptake, total lesion volume, and SUV max of extramedullary disease than sWM patients did ( P < 0.05). None of the visual or semiquantitative indexes in 2-[ 18 F]FDG PET/CT showed significant difference between Waldenström macroglobulinemia and sWM patients.
CONCLUSIONS: [ 68 Ga]Ga-pentixafor PET/CT had better diagnostic performance than 2-[ 18 F]FDG PET/CT in Waldenström macroglobulinemia. Patients with Waldenström macroglobulinemia presented with more extensive extramedullary disease shown in [ 68 Ga]Ga-pentixafor PET/CT than sWM patients did.
RESULTS: Thirty-seven patients with newly diagnosed Waldenström macroglobulinemia and 11 sWM patients were analyzed [35 men and 13 women; 64.3 ± 10.7 (range, 29-87) years old]. The SUV max of bone marrow disease, lymph nodes, and other extramedullary diseases on [ 68 Ga]Ga-pentixafor were significantly higher than those on 2-[ 18 F]FDG PET/CT ( P < 0.05). On [ 68 Ga]Ga-pentixafor PET/CT, patients with Waldenström macroglobulinemia had more lymph node regions involved, significantly higher incidence of involvement in more than three lymph node regions, larger nodal disease, and higher incidence of other extramedullary disease when compared with sWM patients ( P < 0.05). Waldenström macroglobulinemia patients showed significantly higher total lesions uptake, total lesion volume, and SUV max of extramedullary disease than sWM patients did ( P < 0.05). None of the visual or semiquantitative indexes in 2-[ 18 F]FDG PET/CT showed significant difference between Waldenström macroglobulinemia and sWM patients.
CONCLUSIONS: [ 68 Ga]Ga-pentixafor PET/CT had better diagnostic performance than 2-[ 18 F]FDG PET/CT in Waldenström macroglobulinemia. Patients with Waldenström macroglobulinemia presented with more extensive extramedullary disease shown in [ 68 Ga]Ga-pentixafor PET/CT than sWM patients did.
摘要：
背景：区分Waldenström巨球蛋白血症与闷烧的Waldenström巨球蛋白血症（sWM）很重要，因为只有Waldenström巨球蛋白血症患者需要治疗，然而，这种区别在临床上可能很复杂。这项研究的目的是研究[68Ga]Ga-pentixaforPET/CT在sWM和Waldenström巨球蛋白血症患者中是否表现出不同的特征，因此可以帮助区分Waldenström巨球蛋白血症和sWM。
结果：分析了37例新诊断的Waldenström巨球蛋白血症和11例sWM患者[35例男性和13例女性；64.3±10.7（范围，29-87）岁]。骨髓疾病的SUVmax，淋巴结,[68Ga]Ga-pentixafor的其他髓外疾病明显高于2-[18F]FDGPET/CT（P<0.05）。在PET/CT的[68Ga]Ga-pentixa上，患有Waldenström巨球蛋白血症的患者涉及更多的淋巴结区域，三个以上淋巴结区域受累的发生率明显更高，较大的淋巴结病，与sWM患者相比，其他髓外疾病的发生率更高（P<0.05）。Waldenström巨球蛋白血症患者表现出明显更高的总病变摄取，总病变体积,髓外疾病的SUVmax高于sWM患者（P<0.05）。2-[18F]FDGPET/CT中的视觉或半定量指标均未显示Waldenström巨球蛋白血症和sWM患者之间的显着差异。
结论：[68Ga]Ga-pentixa在Waldenström巨球蛋白血症中的诊断性能优于2-[18F]FDGPET/CT。Waldenström巨球蛋白血症患者在PET/CT中显示的髓外疾病比sWM患者更广泛。
结果：分析了37例新诊断的Waldenström巨球蛋白血症和11例sWM患者[35例男性和13例女性；64.3±10.7（范围，29-87）岁]。骨髓疾病的SUVmax，淋巴结,[68Ga]Ga-pentixafor的其他髓外疾病明显高于2-[18F]FDGPET/CT（P<0.05）。在PET/CT的[68Ga]Ga-pentixa上，患有Waldenström巨球蛋白血症的患者涉及更多的淋巴结区域，三个以上淋巴结区域受累的发生率明显更高，较大的淋巴结病，与sWM患者相比，其他髓外疾病的发生率更高（P<0.05）。Waldenström巨球蛋白血症患者表现出明显更高的总病变摄取，总病变体积,髓外疾病的SUVmax高于sWM患者（P<0.05）。2-[18F]FDGPET/CT中的视觉或半定量指标均未显示Waldenström巨球蛋白血症和sWM患者之间的显着差异。
结论：[68Ga]Ga-pentixa在Waldenström巨球蛋白血症中的诊断性能优于2-[18F]FDGPET/CT。Waldenström巨球蛋白血症患者在PET/CT中显示的髓外疾病比sWM患者更广泛。
