PDF(Pubmed)
Abstract：
Reproductive cancers are malignancies that develop in the reproductive organs. One of the leading cancers affecting the male reproductive system on a global scale is prostate cancer (PCa). The negative consequences of PCa metastases endure and are severe, significantly affecting mortality and life quality for those who are affected. The association between inflammation and PCa has captured interest for a while. Inflammatory cells, cytokines, CXC chemokines, signaling pathways, and other elements make up the tumor microenvironment (TME), which is characterized by inflammation. Inflammatory cytokines and CXC chemokines are especially crucial for PCa development and prognosis. Cytokines (interleukins) and CXC chemokines such as IL-1, IL-6, IL-7, IL-17, TGF-β, TNF-α, CXCL1-CXCL6, and CXCL8-CXCL16 are thought to be responsible for the pleiotropic effects of PCa, which include inflammation, progression, angiogenesis, leukocyte infiltration in advanced PCa, and therapeutic resistance. The inflammatory cytokine and CXC chemokines systems are also promising candidates for PCa suppression and immunotherapy. Therefore, the purpose of this work is to provide insight on how the spectra of inflammatory cytokines and CXC chemokines evolve as PCa develops and spreads. We also discussed recent developments in our awareness of the diverse molecular signaling pathways of these circulating cytokines and CXC chemokines, as well as their associated receptors, which may one day serve as PCa-targeted therapies. Moreover, the current status and potential of theranostic PCa therapies based on cytokines, CXC chemokines, and CXC receptors (CXCRs) are examined.
摘要：
生殖癌症是在生殖器官中发展的恶性肿瘤。在全球范围内影响男性生殖系统的主要癌症之一是前列腺癌(PCa)。PCa转移的负面后果持续且严重，显著影响受影响者的死亡率和生活质量。炎症和PCa之间的关联已经引起了人们的兴趣。炎症细胞,细胞因子,CXC趋化因子，信号通路，和其他元素组成肿瘤微环境（TME），以炎症为特征。炎性细胞因子和CXC趋化因子对于PCa的发展和预后尤其重要。细胞因子（白介素）和CXC趋化因子，如IL-1，IL-6，IL-7，IL-17，TGF-β，TNF-α,CXCL1-CXCL6和CXCL8-CXCL16被认为是PCa多效性的原因，包括炎症，programming,血管生成,晚期PCa的白细胞浸润，和治疗抗性。炎性细胞因子和CXC趋化因子系统也是PCa抑制和免疫疗法的有希望的候选物。因此,这项工作的目的是提供有关炎性细胞因子和CXC趋化因子的光谱如何随着PCa的发展和传播而演变的见解。我们还讨论了我们对这些循环细胞因子和CXC趋化因子的不同分子信号通路的认识的最新进展，以及它们相关的受体，这可能有一天作为PCa靶向治疗。此外，基于细胞因子的治疗PCa的现状和潜力，CXC趋化因子，和CXC受体(CXCRs)被检查。
