Abstract：
Biofilm formation is a widespread phenomenon that impacts different fields, including the food industry, agriculture, health care and the environment. Accordingly, there is a serious need for new methods of managing the problem of biofilm formation. Natural products have historically been a rich source of varied compounds with a wide variety of biological functions, including antibiofilm agents. In this review, we critically highlight and discuss the recent progress in understanding the antibiofilm effects of several bioactive compounds isolated from different plants, and in elucidating the underlying mechanisms of action and the factors influencing their adhesion. The literature shows that bioactive compounds have promising antibiofilm potential against both Gram-negative and Gram-positive bacterial and fungal strains, via several mechanisms of action, such as suppressing the formation of the polymer matrix, limiting O2 consumption, inhibiting microbial DNA replication, decreasing hydrophobicity of cell surfaces and blocking the quorum sensing network. This antibiofilm activity is influenced by several environmental factors, such as nutritional cues, pH values, O2 availability and temperature. This review demonstrates that several bioactive compounds could mitigate the problem of biofilm production. However, toxicological assessment and pharmacokinetic investigations of these molecules are strongly required to validate their safety.
摘要：
生物膜形成是影响不同领域的普遍现象,包括食品工业，农业,医疗保健和环境。因此，严重需要管理生物膜形成问题的新方法。天然产物历来是具有多种生物功能的各种化合物的丰富来源，包括抗生物膜剂。在这次审查中,我们批判性地强调并讨论了从不同植物中分离出的几种生物活性化合物的抗生物膜作用的最新进展，并阐明了潜在的作用机制和影响其粘附的因素。文献表明，生物活性化合物对革兰氏阴性和革兰氏阳性细菌和真菌菌株都具有有希望的抗生物膜潜力，通过几种作用机制，例如抑制聚合物基质的形成，限制O2消耗，抑制微生物DNA复制，降低细胞表面的疏水性并阻断群体感应网络。这种抗生物膜活性受几个环境因素的影响，比如营养线索，pH值,O2的可用性和温度。这篇综述表明，几种生物活性化合物可以减轻生物膜产生的问题。然而,迫切需要对这些分子进行毒理学评估和药代动力学研究，以验证其安全性。
