Abstract：
Measles virus is one of the most contagious airborne human viruses which keeps causing outbreaks in numerous countries over the world despite the existence of an efficient vaccine. Fusion inhibitory lipopeptides were shown to inhibit viral entry into target cells, and their adequate administration into the respiratory tract may provide a novel preventive approach against airborne infections. Aerosol delivery presents the best administration route to deliver such preventive compounds to the upper and lower respiratory tract. This approach offers a conceptually new strategy to protect the population at risk against infection by respiratory viruses, including measles. It is a noninvasive needle-free approach, which may be used when antiviral protection is required, without any medical assistance. In this chapter, we describe the nebulization approach of lipopeptide compounds in nonhuman primates and the subsequent measles virus challenge.
摘要：
麻疹病毒是最具传染性的空气传播人类病毒之一，尽管存在有效的疫苗，但仍在世界许多国家/地区引起疫情。融合抑制性脂肽被证明能抑制病毒进入靶细胞，并且将其充分施用到呼吸道中可以提供针对空气传播感染的新的预防方法。气雾剂递送提供了将此类预防性化合物递送至上呼吸道和下呼吸道的最佳施用途径。这种方法提供了一种概念上的新策略，可以保护处于呼吸道病毒感染风险中的人群，包括麻疹.这是一种非侵入性的无针方法，当需要抗病毒保护时可以使用，没有任何医疗援助。在这一章中,我们描述了非人类灵长类动物中脂肽化合物的雾化方法以及随后的麻疹病毒攻击。
