Abstract：
Pancreatic acinar cell carcinoma (PACC) is a rare cancer with no specific treatment. The treatment and chemotherapy for PACC are selected according to pancreatic ductal adenocarcinoma (PDAC). Herein, we describe a recurrent PACC case of an older adult patient. The patient was treated with systemic chemotherapy, chemoradiotherapy, and maintenance therapy based on the pathologic germline BRCA2 variant, resulting in long-term survival. The pathogenic BRCA variant is detected more frequently in patients with PACC than in those with PDAC. The BRCA variant significantly impacts treatment selection and prognosis; therefore, early genomic analysis is recommended when treating PACC.
摘要：
胰腺腺泡细胞癌（PACC）是一种罕见的癌症，没有特异性治疗。根据胰腺导管腺癌(PDAC)选择PACC的治疗和化疗。在这里，我们描述了一例老年患者的复发性PACC病例.患者接受了全身化疗,放化疗,和基于病理性种系BRCA2变异体的维持治疗，导致长期生存。PACC患者比PDAC患者更频繁地检测到致病性BRCA变体。BRCA变异显著影响治疗选择和预后；因此，治疗PACC时,建议进行早期基因组分析.
