Abstract：
BACKGROUND: Recent studies have revealed the usefulness of synovial calprotectin (CLP) in diagnosing chronic periprosthetic joint infections (PJIs). However, there is still a lack of evidence to support the use of serum CLP in the diagnosis of early PJIs and surgical site infections (SSIs) after total joint arthroplasties (TJAs).
OBJECTIVE: The primary aim of this study is to investigate the standard kinetics of CLP concentrations in the blood during the very early postoperative period after non-complicated total hip arthroplasty (THA) and total knee arthroplasty (TKA). The secondary aim was to perform a preliminary comparison of CLP concentrations between non-infected patients and patients with recognized SSIs.
METHODS: A total of 64 consecutive patients who underwent primary THA and TKA were included in this prospective research. Sixty patients (30 THA and 30 TKA) were scheduled to determine the standard shape of the blood CLP curve and the expected concentrations during the first 5 postoperative days after non-complicated TJAs. In 4 additonal patients, early SSI was confirmed, and they were included in a separate SSI subgroup.
RESULTS: Calprotectin demonstrated a linear increase during the first 5 postoperative days. Statistically significant differences in CLP concentrations between non-infected cases and SSIs were not observed. The preoperative median results with interquartile range (Q1-Q3) were 0.52 (0.39-0.64) mg/dL and 0.5 (0.47-0.52) mg/dL (p = 0.77), while post operation they were as follows: on postoperative day 1: 0.88 (0.53-1.3) mg/dL and 0.86 (0.62-1.1) mg/dL (p = 0.84), on postoperative day 3: 1.77 (1.29-2.08) mg/dL and 1.85 (1.70-1.95) mg/dL (p = 0.72), and on postoperative day 5: 2.32 (1.79-2.67) mg/dL and 2.56 (2.25-2.83) mg/dL (p = 0.55), respectively.
CONCLUSIONS: Serial CLP measurements during the early postoperative period revealed a linear (statistically significant) increase in concentration to postoperative day 5 without an evident point of decrease. A significant difference in median values and the course of curve patterns between the non-complicated and SSI groups was not observed.
OBJECTIVE: The primary aim of this study is to investigate the standard kinetics of CLP concentrations in the blood during the very early postoperative period after non-complicated total hip arthroplasty (THA) and total knee arthroplasty (TKA). The secondary aim was to perform a preliminary comparison of CLP concentrations between non-infected patients and patients with recognized SSIs.
METHODS: A total of 64 consecutive patients who underwent primary THA and TKA were included in this prospective research. Sixty patients (30 THA and 30 TKA) were scheduled to determine the standard shape of the blood CLP curve and the expected concentrations during the first 5 postoperative days after non-complicated TJAs. In 4 additonal patients, early SSI was confirmed, and they were included in a separate SSI subgroup.
RESULTS: Calprotectin demonstrated a linear increase during the first 5 postoperative days. Statistically significant differences in CLP concentrations between non-infected cases and SSIs were not observed. The preoperative median results with interquartile range (Q1-Q3) were 0.52 (0.39-0.64) mg/dL and 0.5 (0.47-0.52) mg/dL (p = 0.77), while post operation they were as follows: on postoperative day 1: 0.88 (0.53-1.3) mg/dL and 0.86 (0.62-1.1) mg/dL (p = 0.84), on postoperative day 3: 1.77 (1.29-2.08) mg/dL and 1.85 (1.70-1.95) mg/dL (p = 0.72), and on postoperative day 5: 2.32 (1.79-2.67) mg/dL and 2.56 (2.25-2.83) mg/dL (p = 0.55), respectively.
CONCLUSIONS: Serial CLP measurements during the early postoperative period revealed a linear (statistically significant) increase in concentration to postoperative day 5 without an evident point of decrease. A significant difference in median values and the course of curve patterns between the non-complicated and SSI groups was not observed.
摘要：
背景：最近的研究揭示了滑膜钙卫蛋白（CLP）在诊断慢性假体周围感染（PJIs）中的有用性。然而,目前仍缺乏证据支持血清CLP在诊断全关节置换术(TJAs)后早期PJIs和手术部位感染(SSIs)中的应用.
目的：本研究的主要目的是研究非复杂全髋关节置换术（THA）和全膝关节置换术（TKA）后早期血液中CLP浓度的标准动力学。次要目的是对未感染患者和具有公认SSIs的患者之间的CLP浓度进行初步比较。
方法：本前瞻性研究共纳入了64例接受原发性THA和TKA的连续患者。安排60名患者（30THA和30TKA）在非复杂性TJAs术后的前5天确定血液CLP曲线的标准形状和预期浓度。在4名额外患者中，早期SSI得到确认，他们被纳入一个单独的SSI亚组.
结果：钙卫蛋白在术后前5天呈线性增加。未观察到未感染病例和SSI之间CLP浓度的统计学显着差异。四分位距（Q1-Q3）的术前中位数结果分别为0.52（0.39-0.64）mg/dL和0.5（0.47-0.52）mg/dL（p=0.77），术后第1天：0.88（0.53-1.3）mg/dL和0.86（0.62-1.1）mg/dL（p=0.84），术后第3天：1.77（1.29-2.08）mg/dL和1.85（1.70-1.95）mg/dL（p=0.72），术后第5天：2.32（1.79-2.67）mg/dL和2.56（2.25-2.83）mg/dL（p=0.55），分别。
结论：术后早期的连续CLP测量显示，到术后第5天，浓度呈线性（统计学显著）增加，无明显下降点。未观察到非复杂组和SSI组之间的中值和曲线模式过程的显着差异。
目的：本研究的主要目的是研究非复杂全髋关节置换术（THA）和全膝关节置换术（TKA）后早期血液中CLP浓度的标准动力学。次要目的是对未感染患者和具有公认SSIs的患者之间的CLP浓度进行初步比较。
方法：本前瞻性研究共纳入了64例接受原发性THA和TKA的连续患者。安排60名患者（30THA和30TKA）在非复杂性TJAs术后的前5天确定血液CLP曲线的标准形状和预期浓度。在4名额外患者中，早期SSI得到确认，他们被纳入一个单独的SSI亚组.
结果：钙卫蛋白在术后前5天呈线性增加。未观察到未感染病例和SSI之间CLP浓度的统计学显着差异。四分位距（Q1-Q3）的术前中位数结果分别为0.52（0.39-0.64）mg/dL和0.5（0.47-0.52）mg/dL（p=0.77），术后第1天：0.88（0.53-1.3）mg/dL和0.86（0.62-1.1）mg/dL（p=0.84），术后第3天：1.77（1.29-2.08）mg/dL和1.85（1.70-1.95）mg/dL（p=0.72），术后第5天：2.32（1.79-2.67）mg/dL和2.56（2.25-2.83）mg/dL（p=0.55），分别。
结论：术后早期的连续CLP测量显示，到术后第5天，浓度呈线性（统计学显著）增加，无明显下降点。未观察到非复杂组和SSI组之间的中值和曲线模式过程的显着差异。
