Abstract：
UNASSIGNED: To critically appraise the evidence on the ability of the lacrimal gland ultrasonography (USG) or magnetic resonance imaging (MRI) to differentiate between Sjogren\'s syndrome and non-Sjogren\'s syndrome/healthy controls.
UNASSIGNED: A systematic review and meta-analysis (based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines) of online literature search was performed using PubMed, Scopus, and Cochrane databases. Cohort studies comparing the imaging features of the lacrimal glands of Sjogren\'s syndrome with a control group were included. Quantitative synthesis was performed using the RevMan (Version 5.4.1).
UNASSIGNED: Six studies used USG as an imaging technique, and three used MRI for the lacrimal gland imaging. The lacrimal gland affected with Sjogren\'s syndrome shows glandular heterogeneity on USG and MRI. Heterogeneity on USG had 6.18 times higher odds of the lacrimal gland being involved with Sjogren\'s syndrome (95% CI, 3.31-11.55). Gland hyperechogenicity cannot reliably differentiate the glandular involvement in Sjogren\'s syndrome. There is insufficient data for analysis on the gland size, hypoechoic areas, fibrous bands, and increased lacrimal artery resistance in Sjogren\'s syndrome patients. Of the three MRI-based studies, reduced apparent diffusion coefficient and heterogeneity were the characteristics of Sjogren\'s syndrome. Clinical parameters such as dry eye symptomatology and Schirmer values had variable associations with USG or MRI parameters. Ultrasonography parameters were no different between dry eye versus no dry eye in Sjogren\'s syndrome patients, whereas small-sized glands had low Schirmer on MRI-based studies.
UNASSIGNED: Glandular heterogeneity on USG is significantly associated with lacrimal gland involvement in Sjogren\'s syndrome patients. However, the role of radiology in predicting lacrimal gland involvement is unclear as the evidence is insufficient and heterogeneous.
UNASSIGNED: A systematic review and meta-analysis (based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines) of online literature search was performed using PubMed, Scopus, and Cochrane databases. Cohort studies comparing the imaging features of the lacrimal glands of Sjogren\'s syndrome with a control group were included. Quantitative synthesis was performed using the RevMan (Version 5.4.1).
UNASSIGNED: Six studies used USG as an imaging technique, and three used MRI for the lacrimal gland imaging. The lacrimal gland affected with Sjogren\'s syndrome shows glandular heterogeneity on USG and MRI. Heterogeneity on USG had 6.18 times higher odds of the lacrimal gland being involved with Sjogren\'s syndrome (95% CI, 3.31-11.55). Gland hyperechogenicity cannot reliably differentiate the glandular involvement in Sjogren\'s syndrome. There is insufficient data for analysis on the gland size, hypoechoic areas, fibrous bands, and increased lacrimal artery resistance in Sjogren\'s syndrome patients. Of the three MRI-based studies, reduced apparent diffusion coefficient and heterogeneity were the characteristics of Sjogren\'s syndrome. Clinical parameters such as dry eye symptomatology and Schirmer values had variable associations with USG or MRI parameters. Ultrasonography parameters were no different between dry eye versus no dry eye in Sjogren\'s syndrome patients, whereas small-sized glands had low Schirmer on MRI-based studies.
UNASSIGNED: Glandular heterogeneity on USG is significantly associated with lacrimal gland involvement in Sjogren\'s syndrome patients. However, the role of radiology in predicting lacrimal gland involvement is unclear as the evidence is insufficient and heterogeneous.
摘要：
■严格评估泪腺超声检查（USG）或磁共振成像（MRI）区分干燥综合征和非干燥综合征/健康对照的能力的证据。
■使用PubMed进行了在线文献检索的系统评价和荟萃分析（基于系统评价和荟萃分析指南的首选报告项目），Scopus,和Cochrane数据库。纳入比较干燥综合征与对照组泪腺影像学特征的队列研究。使用RevMan(版本5.4.1)进行定量合成。
■六项研究使用USG作为成像技术，三人使用MRI进行泪腺成像。干燥综合征累及的泪腺在USG和MRI上显示腺体异质性。USG的异质性与干燥综合征相关的泪腺几率高6.18倍(95%CI,3.31-11.55)。腺性高回声不能可靠地区分干燥综合征的腺体受累。没有足够的数据来分析腺体大小，低回声区域,纤维带,干燥综合征患者泪道动脉阻力增加。在三项基于MRI的研究中，表观扩散系数降低和异质性是干燥综合征的特征。诸如干眼症状学和Schirmer值的临床参数与USG或MRI参数具有可变的关联。干燥综合征患者干眼与非干眼的超声检查参数无差异，而在基于MRI的研究中，小型腺体的Schirmer较低。
■USG的腺体异质性与干燥综合征患者的泪腺受累显著相关。然而,放射学在预测泪腺受累中的作用尚不清楚，因为证据不足且不均匀。
■使用PubMed进行了在线文献检索的系统评价和荟萃分析（基于系统评价和荟萃分析指南的首选报告项目），Scopus,和Cochrane数据库。纳入比较干燥综合征与对照组泪腺影像学特征的队列研究。使用RevMan(版本5.4.1)进行定量合成。
■六项研究使用USG作为成像技术，三人使用MRI进行泪腺成像。干燥综合征累及的泪腺在USG和MRI上显示腺体异质性。USG的异质性与干燥综合征相关的泪腺几率高6.18倍(95%CI,3.31-11.55)。腺性高回声不能可靠地区分干燥综合征的腺体受累。没有足够的数据来分析腺体大小，低回声区域,纤维带,干燥综合征患者泪道动脉阻力增加。在三项基于MRI的研究中，表观扩散系数降低和异质性是干燥综合征的特征。诸如干眼症状学和Schirmer值的临床参数与USG或MRI参数具有可变的关联。干燥综合征患者干眼与非干眼的超声检查参数无差异，而在基于MRI的研究中，小型腺体的Schirmer较低。
■USG的腺体异质性与干燥综合征患者的泪腺受累显著相关。然而,放射学在预测泪腺受累中的作用尚不清楚，因为证据不足且不均匀。
