Abstract：
OBJECTIVE: To assess embryonic genital tubercle using transvaginal three-dimensional (3D) ultrasound at 8-10+6 weeks of gestation.
METHODS: One-hundred and two transvaginal 3D ultrasound scans were performed for first-trimester dating at 8-10+6 weeks of gestation. The genital tubercle angle (GTA) and genital tubercle length (GTL) were measured with a mid-sagittal view of the embryo using the 3D ultrasound multiplanar mode. Intra- and inter-observer agreements regarding GTA and GTL were also assessed with Bland-Altman plots and intra- and inter-correlation coefficients.
RESULTS: There were no significant differences in GTA between male and female embryos at 8, 9, 10 weeks, or 8-10+6 weeks of gestation, respectively. There were also no significant differences in GTL between male and female embryos at 8, 9, 10 weeks, or 8-10+6 weeks of gestation, respectively. However, GTL increased linearly with advancing gestation (r=0.8276, p<0.00001). Mean GTL (SD) values at 8, 9, and 10 weeks were 0.833 mm (0.274), 1.623 mm (0.262), and 2.152 mm (0.420), respectively (p<0.001). Intra- and inter-reproducibilities of GTA and GTL were excellent. The intra- and inter-correlation coefficients of GTA and GTL were 0.964 and 0.995, and 0.996 and 0.9933, respectively.
CONCLUSIONS: The genital tubercle could be identified using transvaginal 3D ultrasound at 8-10+6 weeks of gestation. However, sex differentiation could not be performed at this age. The genital tubercle linearly developed with advancing gestation during the mid-first trimester of pregnancy.
METHODS: One-hundred and two transvaginal 3D ultrasound scans were performed for first-trimester dating at 8-10+6 weeks of gestation. The genital tubercle angle (GTA) and genital tubercle length (GTL) were measured with a mid-sagittal view of the embryo using the 3D ultrasound multiplanar mode. Intra- and inter-observer agreements regarding GTA and GTL were also assessed with Bland-Altman plots and intra- and inter-correlation coefficients.
RESULTS: There were no significant differences in GTA between male and female embryos at 8, 9, 10 weeks, or 8-10+6 weeks of gestation, respectively. There were also no significant differences in GTL between male and female embryos at 8, 9, 10 weeks, or 8-10+6 weeks of gestation, respectively. However, GTL increased linearly with advancing gestation (r=0.8276, p<0.00001). Mean GTL (SD) values at 8, 9, and 10 weeks were 0.833 mm (0.274), 1.623 mm (0.262), and 2.152 mm (0.420), respectively (p<0.001). Intra- and inter-reproducibilities of GTA and GTL were excellent. The intra- and inter-correlation coefficients of GTA and GTL were 0.964 and 0.995, and 0.996 and 0.9933, respectively.
CONCLUSIONS: The genital tubercle could be identified using transvaginal 3D ultrasound at 8-10+6 weeks of gestation. However, sex differentiation could not be performed at this age. The genital tubercle linearly developed with advancing gestation during the mid-first trimester of pregnancy.
摘要：
目的：使用经阴道三维（3D）超声评估妊娠8-10+6周的胚胎生殖器结节。
方法：在妊娠8-10+6周时，对孕早期进行了一百零二次经阴道三维超声扫描。使用3D超声多平面模式以胚胎的中矢状视图测量生殖器结节角（GTA）和生殖器结节长度（GTL）。还通过Bland-Altman地块以及内部和相互相关系数评估了有关GTA和GTL的观察者内部和观察者之间的协议。
结果：在8、9、10周时，雄性和雌性胚胎之间的GTA没有显着差异，或妊娠8-10+6周，分别。在8、9、10周时，雄性和雌性胚胎之间的GTL也没有显着差异，或妊娠8-10+6周，分别。然而,GTL随妊娠进展呈线性增加(r=0.8276,p<0.00001)。8、9和10周时的平均GTL（SD）值分别为0.833mm（0.274），1.623mm(0.262),和2.152毫米（0.420），分别(p<0.001)。GTA和GTL的再现性和再现性优异。GTA和GTL的内部和相互相关系数分别为0.964和0.995，0.996和0.9933。
结论：在妊娠8-10+6周时，经阴道三维超声可以识别生殖器结节。然而,在这个年龄段无法进行性别分化.在妊娠中期，随着妊娠的进行，生殖器结节呈线性发展。
方法：在妊娠8-10+6周时，对孕早期进行了一百零二次经阴道三维超声扫描。使用3D超声多平面模式以胚胎的中矢状视图测量生殖器结节角（GTA）和生殖器结节长度（GTL）。还通过Bland-Altman地块以及内部和相互相关系数评估了有关GTA和GTL的观察者内部和观察者之间的协议。
结果：在8、9、10周时，雄性和雌性胚胎之间的GTA没有显着差异，或妊娠8-10+6周，分别。在8、9、10周时，雄性和雌性胚胎之间的GTL也没有显着差异，或妊娠8-10+6周，分别。然而,GTL随妊娠进展呈线性增加(r=0.8276,p<0.00001)。8、9和10周时的平均GTL（SD）值分别为0.833mm（0.274），1.623mm(0.262),和2.152毫米（0.420），分别(p<0.001)。GTA和GTL的再现性和再现性优异。GTA和GTL的内部和相互相关系数分别为0.964和0.995，0.996和0.9933。
结论：在妊娠8-10+6周时，经阴道三维超声可以识别生殖器结节。然而,在这个年龄段无法进行性别分化.在妊娠中期，随着妊娠的进行，生殖器结节呈线性发展。
