Abstract：
Tigecycline is a parenteral glycycline antibiotic that is used to treat severe infections caused by susceptible organisms, butitis also associated with hepatotoxicity. We present 2 similar patients with hepatic steatosis possibly associated with early tigecycline after transplant. In the first case, a 61-year-old woman underwent liver transplant for acute severe hepatitis; 6 days posttransplant, because of nonroutine resistant fever, the patient received tigecycline combined with daptomycin. Retransplant was applied to the patient on day 12 posttransplant because of acute liver failure secondary to hepatic vein thrombosis. After retransplant, biochemical levels gradually increased, exceeding the upper limit of normal. In liver biopsy, the patient had macrovesicular steatosis in 70% to 80% ofthe parenchyma. In the second case, a 53-yearold woman underwent liver transplant for liver cirrhosis. Tigecycline was added to the treatment because of recurrent fever on day 6 after transplant, with treatment also comprising piperacillin-tazobactam and meropenem. On day 15 of the patient\'s tigecycline treatment, her liver function tests were elevated. In liver biopsy, the patient had 30% to 40% macrovesicular steatosis and canalicular cholestasis in the parenchyma, especially in zone 3. Reports of hepatic steatosis associated with early tigecycline after transplant are quite new to the literature.
摘要：
替加环素是一种肠胃外甘霉素抗生素，用于治疗由易感生物引起的严重感染，咽炎也与肝毒性有关。我们介绍了2例类似的肝脂肪变性患者，可能与移植后的早期替加环素有关。在第一种情况下,一名61岁的女性因急性重型肝炎接受了肝移植；移植后6天，因为非常规的耐药热，患者接受替加环素联合达托霉素治疗.由于肝静脉血栓形成继发的急性肝功能衰竭，在移植后第12天对患者进行了再移植。再次移植后,生化水平逐渐升高，超过正常的上限。在肝活检中，患者在70%到80%的实质有大泡性脂肪变性。在第二种情况下，一名53岁的妇女因肝硬化接受了肝移植。由于移植后第6天反复发烧，在治疗中加入了替加环素，治疗还包括哌拉西林他唑巴坦和美罗培南。在患者替加环素治疗的第15天，她的肝功能检查结果升高.在肝活检中，患者实质有30%至40%的大泡性脂肪变性和泪小管淤积，尤其是在3区。移植后与早期替加环素相关的肝脂肪变性的报道对文献来说是相当新的。
