PDF(Pubmed)
Abstract：
Eosinophilic granuloma (EG), a subtype of Langerhans cell histiocytosis (LCH), the monostotic form, is a rare condition characterized by a solitary bone lesion. It is even more unusual for this condition to be accompanied by an epidural hematoma (EDH). This case is unique in that it is the first to involve delayed EDH following a seizure. We describe a remarkable example of EG accompanied by an EDH and consider the rarity of this comorbidity. A 32-month-old boy developed a rapidly growing skull mass following a minor head injury. During surgical preparation for a biopsy, the patient experienced a single convulsion. Imaging following the seizure revealed an EDH in the vicinity of the mass. The mass was excised and confirmed to be an EG, but with positive margins. The patient underwent chemotherapy after systemic skeletal evaluation, in accordance with the LCH III protocol established by the Histiocytosis Society. EG is a rare neoplasm that typically presents as a painless growth on the skull that gradually enlarges over time. The correlation between EG and EDH is exceedingly uncommon, with only a few documented cases. This case study underscores the significance of considering EG in the differential diagnosis of an expanding cranium mass, even when associated with EDH. Prompt diagnosis and treatment can prevent serious complications and improve patient outcomes.
摘要：
嗜酸性肉芽肿(EG),朗格汉斯细胞组织细胞增生症（LCH）的亚型，单骨形式，是一种罕见的疾病，其特征是孤立的骨病变。这种情况伴有硬膜外血肿（EDH）更为罕见。这种情况是独特的，因为它是第一个涉及癫痫发作后延迟EDH的病例。我们描述了EG伴随EDH的显着例子，并考虑了这种共病的罕见性。一名32个月大的男孩在头部轻伤后发展出快速增长的头骨。在活检的手术准备过程中，病人经历了一次抽搐。癫痫发作后的成像显示肿块附近有EDH。切除肿块，确认为EG，但利润率为正。患者在全身骨骼评估后接受化疗，根据组织细胞增生症协会建立的LCHIII方案。EG是一种罕见的肿瘤，通常表现为颅骨上的无痛生长，随着时间的推移逐渐扩大。EG和EDH之间的相关性非常罕见，只有几个记录在案的案例。此案例研究强调了在颅骨肿块扩大的鉴别诊断中考虑EG的重要性，即使与EDH相关联。及时的诊断和治疗可以预防严重的并发症并改善患者的预后。
