PDF(Pubmed)
Abstract：
Hypodontia is the most common dental developmental disorder. Several underlying mechanisms have been proposed to be involved in its pathogenesis. Occurrence of hypodontia as an isolated trait due to genetic mutations has also been reported. Hypodontia most commonly involves the mandibular premolars, maxillary lateral incisors and second premolars. However, hypodontia of permanent second molars is a rare occurrence. To the best of the author\'s knowledge, only two studies on orthodontic patients have reported hypodontia of permanent second molars in Iran. This case report describes non-syndromic bilateral missing of permanent mandibular second molars in a 10-year-old child. Clinical examination revealed no systemic underlying condition, and no clinical evidence of any syndrome, or hereditary or familial pattern. Due to the potential impact of hypodontia on the function of dentition, prompt management of hypodontia is imperative. Furthermore, due to the possible mutations associated with hypodontia, additional screening for cancer susceptibility may be recommended.
摘要：
缺牙症是最常见的牙齿发育障碍。已提出几种潜在的机制涉及其发病机理。也已经报道了由于遗传突变导致的作为分离性状的低体的发生。缺牙症最常见的是下颌前磨牙，上颌侧切牙和第二前磨牙。然而,永久性第二磨牙的低度是罕见的。据作者所知,只有两项关于正畸患者的研究报告了伊朗永久性第二磨牙的牙髓不足。该病例报告描述了一名10岁儿童的永久性下颌第二磨牙的非综合征双侧缺失。临床检查未发现全身潜在疾病，没有任何综合征的临床证据,或遗传或家族模式。由于牙体发育不全对牙列功能的潜在影响，及时管理低聚症势在必行。此外，由于可能的突变与低体相关，可能建议额外筛查癌症易感性.
