PDF(Pubmed)
Abstract：
UNASSIGNED: Children born to mothers living with human immunodeficiency virus (HIV) are at risk for poor health outcomes but data characterizing these associations are limited. Our objective was to determine the impact of maternal viral suppression on growth patterns and malnutrition for infants who are HIV-exposed but uninfected (HEU).
UNASSIGNED: We conducted a retrospective cohort analysis of clinical data for infants who were HEU and their mothers (September 2015 - March 2019) in Kenya. Infants were stratified based on maternal viral suppression status (≥ or <1000 copies/mL); t-tests were used to compare groups. Growth indicators were evaluated with Chi-square, Fisher\'s exact, and area under the curve. Moderate-to-severe underweight status, stunting, and wasting were defined by weight-for-age (WFA), height-for-age (HFA), and weight-for-height (WFH), z-scores ≤2, and were used to define malnutrition. Multivariate logistic regression analyses were performed to evaluate potential associations with malnutrition indicators between WFH and HFA.
UNASSIGNED: Among 674 infants who were HEU, 48.7% were male and 85.0% had mothers who were virally suppressed. The median age at first and last clinic visits was 1.5 and 16.4 months, respectively. WFA and HFA z-scores over time differed by sex, and WFA and HFA differed based on maternal viral suppression (P < 0.05). Male infants had higher adjusted odds for stunted status, and as children aged, they had slightly increased odds of becoming underweight or stunted. Maternal viral suppression and timing of maternal antiretroviral therapy initiation in relation to the prevention of vertical transmission (PVT) enrollment did not significantly affect malnutrition indicators.
UNASSIGNED: Maternal viral suppression status was not associated with increased odds of more severe malnutrition indicators in children who were HEU. However, overall growth patterns over time, measured by z-scores of growth indicators, did differ based on maternal viral suppression status, and to a lesser degree, by gender.
UNASSIGNED: We conducted a retrospective cohort analysis of clinical data for infants who were HEU and their mothers (September 2015 - March 2019) in Kenya. Infants were stratified based on maternal viral suppression status (≥ or <1000 copies/mL); t-tests were used to compare groups. Growth indicators were evaluated with Chi-square, Fisher\'s exact, and area under the curve. Moderate-to-severe underweight status, stunting, and wasting were defined by weight-for-age (WFA), height-for-age (HFA), and weight-for-height (WFH), z-scores ≤2, and were used to define malnutrition. Multivariate logistic regression analyses were performed to evaluate potential associations with malnutrition indicators between WFH and HFA.
UNASSIGNED: Among 674 infants who were HEU, 48.7% were male and 85.0% had mothers who were virally suppressed. The median age at first and last clinic visits was 1.5 and 16.4 months, respectively. WFA and HFA z-scores over time differed by sex, and WFA and HFA differed based on maternal viral suppression (P < 0.05). Male infants had higher adjusted odds for stunted status, and as children aged, they had slightly increased odds of becoming underweight or stunted. Maternal viral suppression and timing of maternal antiretroviral therapy initiation in relation to the prevention of vertical transmission (PVT) enrollment did not significantly affect malnutrition indicators.
UNASSIGNED: Maternal viral suppression status was not associated with increased odds of more severe malnutrition indicators in children who were HEU. However, overall growth patterns over time, measured by z-scores of growth indicators, did differ based on maternal viral suppression status, and to a lesser degree, by gender.
摘要：
患有人类免疫缺陷病毒（HIV）的母亲所生的孩子有健康状况不佳的风险，但表征这些关联的数据有限。我们的目标是确定母体病毒抑制对HIV暴露但未感染（HEU）的婴儿的生长方式和营养不良的影响。
我们对肯尼亚的HEU婴儿及其母亲（2015年9月至2019年3月）的临床数据进行了回顾性队列分析。根据母体病毒抑制状态（≥或<1000拷贝/mL）对婴儿进行分层；使用t检验比较组。生长指标用卡方法评价，费希尔的精确,和曲线下的面积。中度至重度体重不足状态，发育迟缓,消瘦是按年龄体重(WFA)定义的，年龄身高（HFA），和身高体重(WFH)，z分数≤2，用于定义营养不良。进行了多变量逻辑回归分析，以评估WFH和HFA之间与营养不良指标的潜在关联。
■在674名HEU婴儿中，48.7％为男性，85.0％的母亲受到病毒抑制。第一次和最后一次就诊的平均年龄为1.5和16.4个月，分别。随着时间的推移，WFA和HFAz分数因性别而异，WFA和HFA根据母体病毒抑制而有所不同（P<0.05）。男性婴儿发育迟缓的调整几率较高，随着年龄的增长，他们变得体重不足或发育不良的几率略有增加。与预防垂直传播（PVT）相关的母亲病毒抑制和母亲抗逆转录病毒治疗的开始时间没有显着影响营养不良指标。
母亲的病毒抑制状态与HEU患儿出现更严重营养不良指标的几率增加无关。然而,随着时间的推移，整体增长模式，以增长指标的z分数衡量，根据母体病毒抑制状况，确实有所不同，在较小的程度上，按性别。
我们对肯尼亚的HEU婴儿及其母亲（2015年9月至2019年3月）的临床数据进行了回顾性队列分析。根据母体病毒抑制状态（≥或<1000拷贝/mL）对婴儿进行分层；使用t检验比较组。生长指标用卡方法评价，费希尔的精确,和曲线下的面积。中度至重度体重不足状态，发育迟缓,消瘦是按年龄体重(WFA)定义的，年龄身高（HFA），和身高体重(WFH)，z分数≤2，用于定义营养不良。进行了多变量逻辑回归分析，以评估WFH和HFA之间与营养不良指标的潜在关联。
■在674名HEU婴儿中，48.7％为男性，85.0％的母亲受到病毒抑制。第一次和最后一次就诊的平均年龄为1.5和16.4个月，分别。随着时间的推移，WFA和HFAz分数因性别而异，WFA和HFA根据母体病毒抑制而有所不同（P<0.05）。男性婴儿发育迟缓的调整几率较高，随着年龄的增长，他们变得体重不足或发育不良的几率略有增加。与预防垂直传播（PVT）相关的母亲病毒抑制和母亲抗逆转录病毒治疗的开始时间没有显着影响营养不良指标。
母亲的病毒抑制状态与HEU患儿出现更严重营养不良指标的几率增加无关。然而,随着时间的推移，整体增长模式，以增长指标的z分数衡量，根据母体病毒抑制状况，确实有所不同，在较小的程度上，按性别。
