PDF(Pubmed)
Abstract：
UNASSIGNED: Cholera is a life-threatening infectious disease that is still one of the most common acute watery diarrheal diseases in the world today. Acute diarrhea and severe dehydration brought on by cholera can cause hypovolemic shock, which can be fatal in minutes. Without competent clinical therapy, the rate of case fatality surpasses 50%. The purpose of this review was to highlight cholera challenges in Africa and the Middle East and explain the reasons for why this region is currently a fertile environment for cholera. We investigated cholera serology, epidemiology, and the geographical distribution of cholera in Africa and the Middle East in 2022 and 2023. We reviewed detection methods, such as rapid diagnostic tests (RDTs), and treatments, such as antibiotics and phage therapy. Finally, this review explored oral cholera vaccines (OCVs), and the vaccine shortage crisis.
UNASSIGNED: We carried out a systematic search in multiple databases, including PubMed, Web of Science, Google Scholar, Scopus, MEDLINE, and Embase, for studies on cholera using the following keywords: ((Cholera) OR (Vibrio cholera) and (Coronavirus) OR (COVID-19) OR (SARS-CoV2) OR (The Middle East) OR (Africa)).
UNASSIGNED: Cholera outbreaks have increased dramatically, mainly in Africa and many Middle Eastern countries. The COVID-19 pandemic has reduced the attention devoted to cholera and disrupted diagnosis and treatment services, as well as vaccination initiatives. Most of the cholera cases in Africa and the Middle East were reported in Malawi and Syria, respectively, in 2022. RDTs are effective in the early detection of cholera epidemics, especially with limited advanced resources, which is the case in much of Africa. By offering both direct and indirect protection, expanding the use of OCV will significantly reduce the burden of current cholera outbreaks in Africa and the Middle East.
UNASSIGNED: We carried out a systematic search in multiple databases, including PubMed, Web of Science, Google Scholar, Scopus, MEDLINE, and Embase, for studies on cholera using the following keywords: ((Cholera) OR (Vibrio cholera) and (Coronavirus) OR (COVID-19) OR (SARS-CoV2) OR (The Middle East) OR (Africa)).
UNASSIGNED: Cholera outbreaks have increased dramatically, mainly in Africa and many Middle Eastern countries. The COVID-19 pandemic has reduced the attention devoted to cholera and disrupted diagnosis and treatment services, as well as vaccination initiatives. Most of the cholera cases in Africa and the Middle East were reported in Malawi and Syria, respectively, in 2022. RDTs are effective in the early detection of cholera epidemics, especially with limited advanced resources, which is the case in much of Africa. By offering both direct and indirect protection, expanding the use of OCV will significantly reduce the burden of current cholera outbreaks in Africa and the Middle East.
摘要：
霍乱是一种危及生命的传染病，仍然是当今世界上最常见的急性水样腹泻病之一。霍乱引起的急性腹泻和严重脱水可引起低血容量性休克，几分钟内就会致命.没有有效的临床治疗，病死率超过50%。本次审查的目的是强调非洲和中东的霍乱挑战，并解释该地区目前是霍乱的肥沃环境的原因。我们调查了霍乱血清学,流行病学,以及2022年和2023年非洲和中东霍乱的地理分布。我们回顾了检测方法，如快速诊断测试(RDT)，和治疗，如抗生素和噬菌体疗法。最后,这篇综述探讨了口服霍乱疫苗（OCV），以及疫苗短缺危机。
■我们在多个数据库中进行了系统的搜索，包括PubMed,WebofScience,谷歌学者，Scopus,MEDLINE,和Embase,用于霍乱研究，使用以下关键词：（（霍乱）或（霍乱弧菌）和（冠状病毒）或（COVID-19）或（SARS-CoV2）或（中东）或（非洲）。
霍乱疫情急剧增加，主要在非洲和许多中东国家。COVID-19大流行减少了对霍乱的关注，中断了诊断和治疗服务，以及疫苗接种计划。非洲和中东的霍乱病例大多在马拉维和叙利亚报告，分别,2022年。RDT在霍乱流行的早期检测中是有效的，特别是在先进资源有限的情况下，非洲大部分地区都是如此。通过提供直接和间接保护，扩大OCV的使用将显著减轻当前非洲和中东霍乱疫情的负担.
■我们在多个数据库中进行了系统的搜索，包括PubMed,WebofScience,谷歌学者，Scopus,MEDLINE,和Embase,用于霍乱研究，使用以下关键词：（（霍乱）或（霍乱弧菌）和（冠状病毒）或（COVID-19）或（SARS-CoV2）或（中东）或（非洲）。
霍乱疫情急剧增加，主要在非洲和许多中东国家。COVID-19大流行减少了对霍乱的关注，中断了诊断和治疗服务，以及疫苗接种计划。非洲和中东的霍乱病例大多在马拉维和叙利亚报告，分别,2022年。RDT在霍乱流行的早期检测中是有效的，特别是在先进资源有限的情况下，非洲大部分地区都是如此。通过提供直接和间接保护，扩大OCV的使用将显著减轻当前非洲和中东霍乱疫情的负担.
