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Abstract：
Solitary fibrous tumors (SFTs) uncommonly involve the head and neck region. Head and neck SFTs (HNSFTs) exhibit diverse histological features and can mimic several neoplasms with different treatment and behavior. Herein, we report the clinicopathological features of three cases of HNSFT. Case 1 was a 29-year-old female who presented with a nasal cavity mass measuring 3.5 cm. The patient underwent surgical excision. Microscopic examination revealed classic histological and immunohistochemical (IHC) features of SFT. Unusual histological features included epithelioid morphology, clear cells, and edematous change. She developed local recurrence after 11 months, which was also treated with surgery. Case 2 was a 55-year-old male who developed a 1-cm mass at the buccal mucosa. Surgical excision of the tumor was performed. The tumor was completely circumscribed microscopically. Characteristic histological and IHC features of SFT were identified. Unusual histological features observed were an adenomatous pattern, clear cells, and myxoid change. The patient was alive and disease-free at the 12-month follow-up. Case 3 was a 59-year-old female presenting with a medial canthus mass measuring 1.4 cm. The patient underwent surgical excision. Histological and IHC features observed were diagnostic for SFT. Unusual histological features identified were wavy nuclei and multinucleated stromal giant cells. The patient was alive and disease-free at the 124-month follow-up. Diagnosis of SFT can be challenging in unusual locations like the head and neck region. In addition, the histological spectrum of HNSFT is diverse. Therefore, knowledge about unusual histological features and classic IHC expression is essential for establishing correct diagnosis. Long-term follow-up is recommended because of the risk of recurrence in HNSFT.
摘要：
孤立性纤维瘤（SFT）通常累及头颈部。头颈部SFT（HNSFT）表现出不同的组织学特征，并且可以模拟具有不同治疗和行为的几种肿瘤。在这里，我们报告了3例HNSFT的临床病理特征。病例1是一名29岁的女性，其鼻腔肿块为3.5cm。患者接受了手术切除。显微镜检查显示SFT的经典组织学和免疫组织化学（IHC）特征。异常的组织学特征包括上皮样形态，透明细胞,和水肿的变化。11个月后出现局部复发,也接受了手术治疗。病例2是一名55岁的男性，在颊粘膜处出现1厘米的肿块。进行了肿瘤的手术切除。肿瘤在显微镜下被完全限定。确定了SFT的特征性组织学和IHC特征。观察到的异常组织学特征是腺瘤样，透明细胞,和粘液样变化。患者在12个月的随访中存活且无病。病例3是一名59岁的女性，表现为1.4厘米的内侧can块。患者接受了手术切除。观察到的组织学和IHC特征是SFT的诊断。发现的异常组织学特征是波状核和多核基质巨细胞。在124个月的随访中，患者还活着并且没有疾病。在诸如头部和颈部区域的不寻常位置,SFT的诊断可能是具有挑战性的。此外,HNSFT的组织学谱是多样的。因此,有关异常组织学特征和经典IHC表达的知识对于建立正确的诊断至关重要。由于HNSFT复发的风险，建议长期随访。
