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Abstract：
Circular RNAs (circRNAs) are a new type of endogenous non-coding RNA formed by a covalent closed loop. CircRNAs are characterized by specificity, universality, conservation, and stability. They are abundant in eukaryotic cells and have biological regulatory roles at various transcriptional and post-transcriptional levels. The upregulation of circPRKCI has been observed in a variety of tumors and is directly related to the clinicopathological characteristics of tumors and prognosis. More importantly, circPRKCI can participate in the tumorigenesis, progression, recurrence, and metastasis of various tumors through many functional mechanisms, including the activation of signaling pathways, such as the phosphatidylinositol-3-kinase (PI3K)/AKT pathway, and sponging of many microRNAs (miRNAs). This review summarizes the progress achieved in understanding the biological functions of circRNA PRKCI in various tumors. The goal is to inform the discovery of more functional mechanisms and new anticancer molecular targets.
摘要：
环状RNA(circularRNAs,circRNAs)是由共价闭环形成的一类新型内源性非编码RNA。CircRNAs的特征在于特异性，普遍性,养护,和稳定性。它们在真核细胞中丰富，并在各种转录和转录后水平具有生物学调节作用。circPRKCI的上调已在多种肿瘤中观察到，与肿瘤的临床病理特征和预后直接相关。更重要的是,circPRKCI可以参与肿瘤发生，programming,复发,通过许多功能机制转移各种肿瘤，包括信号通路的激活，如磷脂酰肌醇-3-激酶（PI3K）/AKT途径，和许多microRNAs（miRNAs）的海绵。这篇综述总结了在理解circRNAPRKCI在各种肿瘤中的生物学功能方面取得的进展。目标是告知更多功能机制和新的抗癌分子靶标的发现。
