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Abstract：
Germ cell tumors encompass a broad spectrum of neoplasms arising from germ cell lineage, demonstrating varying histological profiles and clinical presentations. These tumors encompass a range of benign and malignant entities. While global trends provide insights into their prevalence, specific regional variations, such as those within North-Western India, remain less explored. This study seeks to bridge this knowledge gap by examining the prevalence and characteristics of germ cell tumors within a tertiary cancer hospital. In this retrospective analysis, all cases of germ cell tumors diagnosed over a 3-year period in the specified tertiary cancer hospital were included. Cases with incomplete records or inadequate pathological data were excluded. Data encompassing histological subtypes, patient age distribution, clinical presentations, and histopathological features were collected and analyzed. The study comprised 145 cases of germ cell tumors. Teratomas were the most prevalent subtype, with mature teratomas accounting for the majority. The highest incidence occurred within the 21-30-year age group with a mean age of 24.77 years. Abdominal mass (56%) and abdominal pain (34%) were the prominent clinical presentations. Benign cases constituted the majority 85.5%. Solid tumors (p < 0.00001) and tumors more than 10 cm (p .029028) were found to have a high propensity to be malignant, which was proven to be statistically significant. This study comprehensively explains germ cell tumors\' prevalence, clinical features, and histopathological subtypes in a tertiary cancer hospital in North-Western India. The predominance of teratomas, particularly mature ones, aligns with global trends. The age distribution and clinical presentations reflect common patterns. The diverse histopathological appearances underscore the heterogeneous nature of germ cell tumors. This study offers valuable insights for clinical management and further regional research.
摘要：
生殖细胞肿瘤包括由生殖细胞谱系引起的广谱肿瘤，显示不同的组织学特征和临床表现。这些肿瘤包括一系列良性和恶性实体。虽然全球趋势提供了对其患病率的见解，特定的区域差异，比如印度西北部的那些，少探索。这项研究旨在通过检查三级癌症医院内生殖细胞肿瘤的患病率和特征来弥合这一知识鸿沟。在这个回顾性分析中,纳入了在指定三级癌症医院3年内诊断的所有生殖细胞肿瘤病例.排除记录不完整或病理资料不充分的病例。包括组织学亚型的数据，患者年龄分布,临床表现,收集并分析组织病理学特征。该研究包括145例生殖细胞肿瘤。畸胎瘤是最常见的亚型,成熟的畸胎瘤占大多数。最高的发病率发生在21-30岁年龄组，平均年龄为24.77岁。腹部肿块（56％）和腹痛（34％）是突出的临床表现。良性病例占多数85.5%。发现实体肿瘤（p<0.00001）和超过10厘米的肿瘤（p.029028）具有很高的恶性倾向，这被证明具有统计学意义。这项研究全面解释了生殖细胞肿瘤的患病率，临床特征,以及印度西北部一家三级癌症医院的组织病理学亚型。畸胎瘤占主导地位,特别是成熟的，与全球趋势保持一致。年龄分布和临床表现反映了共同的模式。不同的组织病理学表现强调了生殖细胞肿瘤的异质性。这项研究为临床管理和进一步的区域研究提供了有价值的见解。
