PDF(Pubmed)
Abstract：
Ovarian mature cystic teratomas comprise tissue derived from all three germ layers and constitute 10-20% of all ovarian neoplasms. Malignant transformation of mature cystic teratomas (MCT) is very rare with an incidence of 0.17-2%. The most frequently reported malignancies include squamous cell carcinoma and adenocarcinoma. Herein, we describe a case of a 56-year-old female who presented with abdominal pain and underwent total abdominal hysterectomy with bilateral oophorectomy and omentectomy for a ruptured dermoid cyst. Histological examination showed nests of pleomorphic cells with prominent nucleoli and melanin pigment in the background of a mature cystic teratoma. These cells showed immunoreactivity for Melan-A and HMB-45, thus confirming the diagnosis of malignant transformation of a mature cystic teratoma to a malignant melanoma.
摘要：
卵巢成熟囊性畸胎瘤包括来自所有三个胚层的组织，占所有卵巢肿瘤的10-20％。成熟囊性畸胎瘤（MCT）的恶性转化非常罕见，发生率为0.17-2％。最常报道的恶性肿瘤包括鳞状细胞癌和腺癌。在这里，我们描述了一例56岁的女性患者，她出现腹痛，并接受了全腹子宫切除术，双侧卵巢切除术和网膜切除术治疗破裂皮样囊肿。组织学检查显示，在成熟的囊性畸胎瘤背景下，多形性细胞的巢具有明显的核仁和黑色素。这些细胞对Melan-A和HMB-45显示出免疫反应性，从而证实了成熟的囊性畸胎瘤恶性转化为恶性黑色素瘤的诊断。
