Abstract：
MALT lymphoma of the dura is a very rare type of low-grade B-cell lymphoma. Little more than 100 cases have been reported in the literature to date. We report a 43-year-old woman who was referred to hospital because of a series of three tonic-clonic seizures on the day of admission. Neurological examination revealed confusion and aphasia. Magnetic resonance imaging (MRI) showed a contrast-enhanced, broad-based lesion along the dura in the left parieto-occipital area. The suspicion of an en plaque meningioma was raised. The tumour invaded the brain parenchyma with visible extension into the brain sulci. There was a marked brain oedema surrounding the lesion and causing the midline shift 8 mm to the right. After stabilization of neurological condition (intravenous diuretics and steroids), the operation was performed. The diagnosis of dural MALT lymphoma was established. During the pathological examination, it was especially problematic to distinguish MALT lymphoma from follicular lymphoma, but the final diagnosis was MALT lymphoma. Surgical partial removal with additional R-CVP immunochemotherapy (rituximab, cyclophosphamide, vincristine and prednisone) resulted in complete remission. The follow-up period is 1 year. Our presented case of a MALT lymphoma highlights the fact that surgical partial removal with additional immunochemotherapy is an available option in these rare intracranial tumours.
摘要：
硬脑膜的MALT淋巴瘤是一种非常罕见的低度B细胞淋巴瘤。迄今为止，文献中报道的病例不超过100例。我们报告了一名43岁的妇女，她在入院当天因一系列三次强直阵挛性癫痫发作而被转诊到医院。神经系统检查显示意识模糊和失语症。磁共振成像（MRI）显示对比增强，沿左侧顶枕区硬脑膜的广泛病变。提出了对斑块状脑膜瘤的怀疑。肿瘤侵入脑实质，并可见延伸到脑沟。病变周围有明显的脑水肿，并导致中线向右偏移8mm。神经系统疾病（静脉利尿剂和类固醇）稳定后，手术进行了。诊断为硬膜MALT淋巴瘤。在病理检查期间，区分MALT淋巴瘤和滤泡性淋巴瘤尤其成问题，但最终诊断为MALT淋巴瘤。手术部分切除并额外进行R-CVP免疫化学疗法（利妥昔单抗，环磷酰胺,长春新碱和泼尼松）导致完全缓解。随访期为1年。我们提出的MALT淋巴瘤病例强调了以下事实：在这些罕见的颅内肿瘤中，手术部分切除并进行额外的免疫化疗是一种可行的选择。
