PDF(Pubmed)
Abstract：
Calcium (Ca2+) is a highly versatile intracellular messenger that regulates several cellular processes. Although it is unclear how a single-second messenger coordinates various effects within a cell, there is growing evidence that spatial patterns of Ca2+ signals play an essential role in determining their specificity. Ca2+ signaling patterns can differ in various cell regions, and Ca2+ signals in the nuclear and cytoplasmic compartments have been observed to occur independently. The initiation and function of Ca2+ signaling within the nucleus are not yet fully understood. Receptor tyrosine kinases (RTKs) induce Ca2+ signaling resulting from phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and inositol 1,4,5-trisphosphate (InsP3) formation within the nucleus. This signaling mechanism may be responsible for the effects of specific growth factors on cell proliferation and gene transcription. This review highlights the recent advances in RTK trafficking to the nucleus and explains how these receptors initiate nuclear calcium signaling.
摘要：
钙（Ca2）是一种高度通用的细胞内信使，可调节多种细胞过程。虽然目前还不清楚单秒信使如何协调细胞内的各种效应，越来越多的证据表明，Ca2+信号的空间模式在确定其特异性中起着至关重要的作用。Ca2+信号模式可以在不同的细胞区域不同，已经观察到细胞核和细胞质区室中的Ca2信号独立发生。细胞核内Ca2+信号的启动和功能尚未完全了解。受体酪氨酸激酶(RTK)诱导由磷脂酰肌醇4,5-二磷酸(PIP2)水解和核内肌醇1,4,5-三磷酸(InsP3)形成产生的Ca2+信号传导。这种信号传导机制可能与特定生长因子对细胞增殖和基因转录的影响有关。这篇综述强调了RTK转运到细胞核的最新进展，并解释了这些受体如何启动细胞核钙信号传导。
