Abstract：
OBJECTIVE: To illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeletal development under normal and pathological conditions.
RESULTS: Recent data obtained from studies on zebrafish have demonstrated the genetic redundancy of Fgf signaling pathway and have identified new molecular partners of this signaling during the early stages of craniofacial skeletal development. Studies on zebrafish models demonstrate the involvement of the Fgf signaling pathway at every stage of craniofacial development. They particularly emphasize the central role of Fgf signaling pathway during the early stages of the development, which significantly impacts the formation of the various structures making up the craniofacial skeleton. This partly explains the craniofacial abnormalities observed in disorders associated with FGF signaling. Future research efforts should focus on investigating zebrafish Fgf signaling during more advanced stages, notably by establishing zebrafish models expressing mutations responsible for diseases such as craniosynostoses.
RESULTS: Recent data obtained from studies on zebrafish have demonstrated the genetic redundancy of Fgf signaling pathway and have identified new molecular partners of this signaling during the early stages of craniofacial skeletal development. Studies on zebrafish models demonstrate the involvement of the Fgf signaling pathway at every stage of craniofacial development. They particularly emphasize the central role of Fgf signaling pathway during the early stages of the development, which significantly impacts the formation of the various structures making up the craniofacial skeleton. This partly explains the craniofacial abnormalities observed in disorders associated with FGF signaling. Future research efforts should focus on investigating zebrafish Fgf signaling during more advanced stages, notably by establishing zebrafish models expressing mutations responsible for diseases such as craniosynostoses.
摘要：
目的：说明在正常和病理条件下，使用斑马鱼了解Fgf信号通路在颅面骨骼发育过程中的作用的价值。
结果：从斑马鱼研究中获得的最新数据已经证明了Fgf信号通路的遗传冗余，并在颅面骨骼发育的早期阶段确定了该信号的新分子伴侣。斑马鱼模型的研究表明，Fgf信号通路参与颅面发育的每个阶段。他们特别强调Fgf信号通路在发育早期的中心作用，这极大地影响了构成颅面骨骼的各种结构的形成。这部分解释了在与FGF信号传导相关的疾病中观察到的颅面异常。未来的研究工作应该集中在更晚期阶段的斑马鱼Fgf信号研究上，特别是通过建立斑马鱼模型，表达与颅骨滑膜病等疾病有关的突变。
结果：从斑马鱼研究中获得的最新数据已经证明了Fgf信号通路的遗传冗余，并在颅面骨骼发育的早期阶段确定了该信号的新分子伴侣。斑马鱼模型的研究表明，Fgf信号通路参与颅面发育的每个阶段。他们特别强调Fgf信号通路在发育早期的中心作用，这极大地影响了构成颅面骨骼的各种结构的形成。这部分解释了在与FGF信号传导相关的疾病中观察到的颅面异常。未来的研究工作应该集中在更晚期阶段的斑马鱼Fgf信号研究上，特别是通过建立斑马鱼模型，表达与颅骨滑膜病等疾病有关的突变。
