Abstract：
Our aim in this study is to evaluate the cardiovascular findings of pediatric patients with primary Raynaud\'s phenomenon (RP) and to determine if there are any pathological findings. Our study included 42 pediatric patients aged between 7 and 18 who were diagnosed with primary RP and did not have any additional underlying structural vascular disease or secondary rheumatological conditions. The control group consisted of 30 healthy volunteers aged 7-18 years, matched by age and sex, without any additional diseases. We evaluated demographic, clinical, and laboratory findings, echocardiographic and capillaroscopic features, as well as carotid intima-media thickness. Compared to the control group, pediatric patients with primary RP showed increased A wave velocity and E/E\' ratio parameters in the left ventricle, indicating diastolic dysfunction of the heart. The isovolumetric relaxation time (IVRT) was prolonged in both the left and right ventricles, and the E/A ratio decreased in the left ventricle. The myocardial performance index (MPI), indicating both systolic and diastolic dysfunction, increased in both ventricles. Additionally, the aortic stiffness index, aortic elastic modulus (Ep), and left carotid intima-media thickness (CIMT) significantly increased, while distensibility decreased in pediatric patients with primary RP compared to the control group. The cardiovascular evaluation of pediatric patients with primary RP revealed that diastolic dysfunction is likely present in both the left and right heart. Additionally, based on the aorta and carotid intima measurements, it is suggested that pediatric patients with primary RP are at risk for developing atherosclerosis.
摘要：
我们在这项研究中的目的是评估患有原发性雷诺现象（RP）的儿科患者的心血管发现，并确定是否有任何病理发现。我们的研究包括42名年龄在7至18岁之间的儿科患者，这些患者被诊断为原发性RP，并且没有任何其他潜在的结构性血管疾病或继发性风湿病。对照组由30名7-18岁的健康志愿者组成，年龄和性别相匹配，没有任何额外的疾病。我们评估了人口统计，临床,和实验室发现，超声心动图和毛细管镜特征，以及颈动脉内膜中层厚度.与对照组相比,原发性RP的儿科患者显示左心室A波速度和E/E比值参数增加，表明心脏舒张功能障碍。左心室和右心室的等容弛豫时间（IVRT）延长，左心室E/A比值下降。心肌性能指标(MPI),显示收缩和舒张功能障碍,在两个心室增加。此外,主动脉硬度指数,主动脉弹性模量（Ep），左颈动脉内中膜厚度（CIMT）明显增加，与对照组相比，原发性RP患儿的扩张性降低。对患有原发性RP的儿科患者的心血管评估显示，左心和右心都可能存在舒张功能障碍。此外,基于主动脉和颈动脉内膜的测量,提示原发性RP的儿科患者有发生动脉粥样硬化的风险.
