Abstract：
Time-to-event endpoints are widely used as measures of patients\' well-being and indicators of prognosis. In imaging-based biomarker studies, there are increasingly more studies that focus on examining imaging biomarkers\' prognostic or predictive utilities on those endpoints, whether in a trial or an observational study setting. In this educational review article, we briefly introduce some basic concepts of time-to-event endpoints and point out potential pitfalls in the context of imaging biomarker research in hope of improving radiologists\' understanding of related subjects. Besides, we have included some review and discussions on the benefits of using time-to-event endpoints and considerations on selecting overall survival or progression-free survival for primary analysis. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 3.
摘要：
时间至事件终点被广泛用作患者幸福感和预后指标。在基于成像的生物标志物研究中，越来越多的研究专注于检查成像生物标志物对这些终点的预后或预测效用，无论是在试验还是观察性研究环境中。在这篇教育评论文章中，我们简要介绍了时间至事件终点的一些基本概念,并指出了影像学生物标志物研究的潜在陷阱,以期提高放射科医师对相关学科的理解.此外,我们纳入了一些关于使用时间至事件终点的益处的回顾和讨论,以及选择总生存期或无进展生存期进行主要分析的考虑因素.证据水平：5技术效率：第3阶段。
