PDF(Pubmed)
Abstract：
Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.
摘要：
长链非编码RNA（LncRNA）是基因表达的关键调节因子，可以介导它们在细胞核和细胞质中的作用。一些特征最好的lncRNAs位于细胞核内，它们调节核结构并影响基因表达。在这次审查中,我们讨论了lncRNAs在先天免疫中基因调控功能的背景下在核结构中的作用。这里,我们讨论了在功能上表征核定位lncRNAs的各种方法以及该领域面临的挑战。
