Abstract：
Oral metastatic sarcomas (OMSs) occur only occasionally, and information about their characteristics is based on the restricted number of cases reported in the literature. This study aims to systematically review the English literature to recognize the clinicopathologic characteristics of OMSs. An electronic search was performed in PubMed Central and Scopus databases. The search included all the published articles (human case reports and case series) up till April 2023, with no time restrictions. OMSs were slightly more prevalent in males in their fifth to seventh decades of life. However, a high percentage of OMSs has been reported in the second decade of life. Lower extremities, breasts and uterus are the most common primary origin of metastatic sarcoma. Gingiva and mandible were common locations in the oral cavity for metastatic deposits. Generally, they demonstrated widespread affliction. The mean time interval between primary tumor detection and diagnosis of the oral metastasis was about 33.54 ± 36.19 months. Death was reported in 83 patients (67.48 %) with a mean survival rate of 7.98 ± 10.30 months. The most common microscopic tumor types were leiomyosarcoma (n = 21, 17 %), followed by angiosarcoma (n = 20, 16.26 %) and osteosarcoma (n = 18, 14.63 %). In conclusion, while oral metastases of sarcomas are not common, those should be considered in the differential diagnosis of the oral lesions. Although OMSs show a high occurrence in the 7th decade of the life, the average age of patients with oral involvement is lower than the overall metastatic lesions. OMSs may present as widespread disease with poor prognosis.
摘要：
口腔转移性肉瘤（OMS）仅偶尔发生，有关其特征的信息是基于文献中报告的有限病例数。本研究旨在系统回顾英文文献，以认识OMSs的临床病理特征。在PubMedCentral和Scopus数据库中进行了电子搜索。搜索包括直到2023年4月的所有已发表的文章（人类病例报告和病例系列），没有时间限制。OMS在男性的第五到七十年中更为普遍。然而,据报道，在生命的第二个十年中，OMS的比例很高。下肢,乳房和子宫是转移性肉瘤最常见的原发来源。牙龈和下颌骨是口腔中转移沉积物的常见位置。一般来说,他们表现出广泛的痛苦。原发肿瘤检出与口腔转移诊断的平均时间间隔约为33.54±36.19个月。报告83例患者（67.48％）死亡，平均生存率为7.98±10.30个月。最常见的微观肿瘤类型是平滑肌肉瘤（n=21，17％），其次是血管肉瘤(n=20,16.26%)和骨肉瘤(n=18,14.63%)。总之,虽然肉瘤的口腔转移并不常见，在口腔病变的鉴别诊断中应考虑这些因素。尽管OMS在生命的第七个十年中显示出很高的发生率，口腔受累患者的平均年龄低于总体转移性病变。OMS可能表现为广泛的疾病，预后不良。
