PDF(Pubmed)
Abstract：
Tendons are fibroblastic structures that link muscle and bone. There are two kinds of tendon injuries, including acute and chronic. Each form of injury or deterioration can result in significant pain and loss of tendon function. The recovery of tendon damage is a complex and time-consuming recovery process. Depending on the anatomical location of the tendon tissue, the clinical outcomes are not the same. The healing of the wound process is divided into three stages that overlap: inflammation, proliferation, and tissue remodeling. Furthermore, the curing tendon has a high re-tear rate. Faced with the challenges, tendon injury management is still a clinical issue that must be resolved as soon as possible. Several newer directions and breakthroughs in tendon recovery have emerged in recent years. This article describes tendon injury and summarizes recent advances in tendon recovery, along with stem cell therapy, gene therapy, Platelet-rich plasma remedy, growth factors, drug treatment, and tissue engineering. Despite the recent fast-growing research in tendon recovery treatment, still, none of them translated to the clinical setting. This review provides a detailed overview of tendon injuries and potential preclinical approaches for treating tendon injuries.
摘要：
肌腱是连接肌肉和骨骼的成纤维细胞结构。有两种肌腱损伤，包括急性和慢性。每种形式的损伤或恶化都会导致明显的疼痛和肌腱功能丧失。肌腱损伤的恢复是一个复杂而耗时的恢复过程。根据肌腱组织的解剖位置，临床结果不一样.伤口愈合过程分为三个重叠阶段：炎症，扩散,和组织重塑。此外，固化肌腱具有高的再撕裂率。面对挑战,肌腱损伤的处理仍然是一个必须尽快解决的临床问题。近年来，肌腱恢复出现了几个新的方向和突破。本文介绍了肌腱损伤，并总结了肌腱恢复的最新进展，随着干细胞治疗，基因治疗,富含血小板的血浆药物，生长因子，药物治疗,和组织工程。尽管最近在肌腱恢复治疗方面的研究快速增长，仍然,它们都没有转化为临床环境。这篇综述提供了肌腱损伤和治疗肌腱损伤的潜在临床前方法的详细概述。
