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Abstract：
UNASSIGNED: This study aimed to ascertain the microbial profiles and predisposing risk factors for microbial keratitis and to analyze the trend of mixed microbial infection cases over 8 years.
UNASSIGNED: In this retrospective analysis, we reviewed the electronic medical records of inpatients diagnosed with microbial keratitis between January 2012 and December 2019. Data on demographics, risk factors, and causative pathogens were analyzed. Multivariate logistic regression models were utilized to identify risk factors associated with pathogens.
UNASSIGNED: This study included 640 eyes of 638 patients. Trauma was the most common predisposing risk factor (57.2%), followed by a combination of factors (14.4%). Among diagnostic test results, bacteria, fungi, and mixed pathogens were identified in 46.72%, 46.56%, and 21.41% of cases, respectively. Positive culture results were obtained in 324 eyes (53.6%), with Pseudomonas aeruginosa (25.1%) and Fusarium spp. (17.4%) being the most prevalent pathogens. In the multivariate logistic regression model, contact lens use, presence of diabetes mellitus, and HIV infection were statistically significant risk factors for Pseudomonas aeruginosa infection (p = 0.001, p = 0.046, and p = 0.04, respectively). Trauma was associated with Fusarium spp. infection (p = 0.001). An increase in the percentage of mixed microbial infection cases was observed when comparing the periods of 2016-2019 with 2012-2015 (p = 0.023).
UNASSIGNED: Bacteria and fungi are equally common causes of microbial keratitis, with Pseudomonas aeruginosa and Fusarium spp. being the predominant pathogens causing bacterial and fungal infections. Trauma is the primary predisposing risk factor for microbial keratitis. There was a notable increase in mixed infection cases over the study period.
UNASSIGNED: In this retrospective analysis, we reviewed the electronic medical records of inpatients diagnosed with microbial keratitis between January 2012 and December 2019. Data on demographics, risk factors, and causative pathogens were analyzed. Multivariate logistic regression models were utilized to identify risk factors associated with pathogens.
UNASSIGNED: This study included 640 eyes of 638 patients. Trauma was the most common predisposing risk factor (57.2%), followed by a combination of factors (14.4%). Among diagnostic test results, bacteria, fungi, and mixed pathogens were identified in 46.72%, 46.56%, and 21.41% of cases, respectively. Positive culture results were obtained in 324 eyes (53.6%), with Pseudomonas aeruginosa (25.1%) and Fusarium spp. (17.4%) being the most prevalent pathogens. In the multivariate logistic regression model, contact lens use, presence of diabetes mellitus, and HIV infection were statistically significant risk factors for Pseudomonas aeruginosa infection (p = 0.001, p = 0.046, and p = 0.04, respectively). Trauma was associated with Fusarium spp. infection (p = 0.001). An increase in the percentage of mixed microbial infection cases was observed when comparing the periods of 2016-2019 with 2012-2015 (p = 0.023).
UNASSIGNED: Bacteria and fungi are equally common causes of microbial keratitis, with Pseudomonas aeruginosa and Fusarium spp. being the predominant pathogens causing bacterial and fungal infections. Trauma is the primary predisposing risk factor for microbial keratitis. There was a notable increase in mixed infection cases over the study period.
摘要：
■本研究旨在确定微生物性角膜炎的微生物概况和易感危险因素，并分析8年来混合微生物感染病例的趋势。
■在此回顾性分析中，我们回顾了2012年1月至2019年12月期间诊断为微生物性角膜炎的住院患者的电子病历.人口统计数据，危险因素，并对病原菌进行了分析。多因素logistic回归模型用于确定与病原体相关的危险因素。
■这项研究包括638名患者的640只眼。创伤是最常见的诱发风险因素（57.2%），其次是综合因素(14.4%)。在诊断测试结果中，细菌,真菌,混合病原菌占46.72%，46.56%,和21.41%的病例，分别。324眼（53.6％）获得阳性培养结果，铜绿假单胞菌（25.1％）和镰刀菌属。（17.4％）是最常见的病原体。在多元逻辑回归模型中，隐形眼镜使用，糖尿病的存在，和HIV感染是铜绿假单胞菌感染的具有统计学意义的危险因素（分别为p=0.001，p=0.046和p=0.04）。创伤与镰刀菌属有关。感染（p=0.001）。比较2016-2019年与2012-2015年期间，观察到混合微生物感染病例的百分比增加（p=0.023）。
■细菌和真菌同样是微生物性角膜炎的常见原因，铜绿假单胞菌和镰刀菌。是引起细菌和真菌感染的主要病原体。创伤是微生物性角膜炎的主要易感危险因素。在研究期间，混合感染病例明显增加。
■在此回顾性分析中，我们回顾了2012年1月至2019年12月期间诊断为微生物性角膜炎的住院患者的电子病历.人口统计数据，危险因素，并对病原菌进行了分析。多因素logistic回归模型用于确定与病原体相关的危险因素。
■这项研究包括638名患者的640只眼。创伤是最常见的诱发风险因素（57.2%），其次是综合因素(14.4%)。在诊断测试结果中，细菌,真菌,混合病原菌占46.72%，46.56%,和21.41%的病例，分别。324眼（53.6％）获得阳性培养结果，铜绿假单胞菌（25.1％）和镰刀菌属。（17.4％）是最常见的病原体。在多元逻辑回归模型中，隐形眼镜使用，糖尿病的存在，和HIV感染是铜绿假单胞菌感染的具有统计学意义的危险因素（分别为p=0.001，p=0.046和p=0.04）。创伤与镰刀菌属有关。感染（p=0.001）。比较2016-2019年与2012-2015年期间，观察到混合微生物感染病例的百分比增加（p=0.023）。
■细菌和真菌同样是微生物性角膜炎的常见原因，铜绿假单胞菌和镰刀菌。是引起细菌和真菌感染的主要病原体。创伤是微生物性角膜炎的主要易感危险因素。在研究期间，混合感染病例明显增加。
