PDF(Pubmed)
Abstract：
Catastrophic antiphospholipid antibody syndrome is a rare and severe subtype of antiphospholipid syndrome with multisystemic organ failure due to thromboembolic events, resulting in high mortality rates. The association between catastrophic antiphospholipid antibody syndrome and autoimmune thyroid diseases is rarely reported in the literature. We report a case of a 35-year-old previously healthy female with Graves\' thyroid storm, positive lupus antibodies, and probable catastrophic antiphospholipid antibody syndrome. Her hospital course was complicated by extensive venous thromboembolism, superior vena cava syndrome, thromboembolic strokes, and Takotsubo cardiomyopathy. Eventually, this led to an unfortunate death secondary to profound shock after 8 days despite emergent treatment. Our case report discusses the link between autoimmune thyroid disorders and catastrophic antiphospholipid antibody syndrome. We emphasize the difficulty in diagnosing catastrophic antiphospholipid antibody syndrome in extremely ill patients and stress the significance of considering it as a possible cause in thyrotoxicosis patients with multiple organ failure and hypercoagulability. Early recognition and prompt management are crucial in improving outcomes in these patients.
摘要：
灾难性抗磷脂抗体综合征是一种罕见且严重的抗磷脂综合征亚型，由于血栓栓塞事件导致多系统器官衰竭，导致高死亡率。在文献中很少报道灾难性抗磷脂抗体综合征与自身免疫性甲状腺疾病之间的关联。我们报告了一例35岁以前健康的女性患有Graves\'甲状腺风暴，狼疮抗体阳性,和可能的灾难性抗磷脂抗体综合征。她的住院过程因广泛的静脉血栓栓塞而复杂化，上腔静脉综合征,血栓栓塞性中风,和Takotsubo心肌病。最终,尽管紧急治疗，但这导致8天后因严重震惊而不幸死亡。我们的病例报告讨论了自身免疫性甲状腺疾病与灾难性抗磷脂抗体综合征之间的联系。我们强调在重症患者中诊断灾难性抗磷脂抗体综合征的困难，并强调将其视为多器官衰竭和高凝状态的甲状腺毒症患者的可能原因的重要性。早期识别和及时管理对于改善这些患者的预后至关重要。
