PDF(Pubmed)
Abstract：
UNASSIGNED: The unappealing appearance of skin in macular amyloidosis (MA) interferes with the patient\'s quality of life, and treating the condition has been challenging.
UNASSIGNED: To compare the efficacy and safety of 15% trichloroacetic acid (TCA) peel, 35% glycolic acid (GA) peel, and Q-switched Nd-YAG Laser in MA.
UNASSIGNED: Open, prospective study was conducted over 2 years, where after fulfilling the criteria, randomization was done into three groups. Group A: 15% TCA peel; Group B: 35% GA peel; Group C: Q-switched Nd-YAG Laser. Procedures were repeated at monthly intervals for six sittings. On each visit, patients were scored on the following parameters: color score, visual analog score (VAS), physician global assessment (PGA) scale, subjective improvement, and adverse effects.
UNASSIGNED: A total of 75 patients (25 patients in each group) completed the treatment. The mean age of study-population was 35.68 ± 9.8 years, with female to male ratio of 11.5:1. The mean change in color score (1.68) was more by Group A, followed by Group C (1.4), followed by Group B (1.16). Similar results were noted by subjective improvement, VAS, and PGA. Adverse events were more in Group A, followed by Group C, followed by Group B. No patient showed permanent adverse events.
UNASSIGNED: TCA-peel showed superior results over Nd-YAG laser and glycolic-acid peel. TCA-peel being cost-effective with excellent acceptability should be considered a treatment modality.
UNASSIGNED: To compare the efficacy and safety of 15% trichloroacetic acid (TCA) peel, 35% glycolic acid (GA) peel, and Q-switched Nd-YAG Laser in MA.
UNASSIGNED: Open, prospective study was conducted over 2 years, where after fulfilling the criteria, randomization was done into three groups. Group A: 15% TCA peel; Group B: 35% GA peel; Group C: Q-switched Nd-YAG Laser. Procedures were repeated at monthly intervals for six sittings. On each visit, patients were scored on the following parameters: color score, visual analog score (VAS), physician global assessment (PGA) scale, subjective improvement, and adverse effects.
UNASSIGNED: A total of 75 patients (25 patients in each group) completed the treatment. The mean age of study-population was 35.68 ± 9.8 years, with female to male ratio of 11.5:1. The mean change in color score (1.68) was more by Group A, followed by Group C (1.4), followed by Group B (1.16). Similar results were noted by subjective improvement, VAS, and PGA. Adverse events were more in Group A, followed by Group C, followed by Group B. No patient showed permanent adverse events.
UNASSIGNED: TCA-peel showed superior results over Nd-YAG laser and glycolic-acid peel. TCA-peel being cost-effective with excellent acceptability should be considered a treatment modality.
摘要：
■黄斑淀粉样变性（MA）中皮肤的不吸引人的外观干扰了患者的生活质量，治疗这种疾病一直具有挑战性。
■为了比较15％三氯乙酸（TCA）果皮的功效和安全性，35%乙醇酸(GA)果皮,和Q开关Nd-YAG激光器在MA。
■打开，前瞻性研究进行了2年，在满足标准之后，随机分为三组.A组:15%TCA剥离;B组:35%GA剥离;C组:Q开关Nd-YAG激光。每月一次重复该程序，共进行六次。每次访问,患者根据以下参数进行评分：颜色评分，视觉模拟评分(VAS)，医师全球评估(PGA)量表，主观改进,和不利影响。
■共有75名患者（每组25名患者）完成了治疗。研究人群的平均年龄为35.68±9.8岁，男女比例为11.5:1。A组颜色评分的平均变化（1.68）更大，其次是C组(1.4)，其次是B组（1.16）。类似的结果是通过主观改进注意到的，VAS,和PGA。A组的不良事件更多，其次是C组，其次是B组。无患者出现永久性不良事件。
■TCA剥离显示优于Nd-YAG激光和乙醇酸剥离的结果。TCA剥离具有良好的可接受性，具有成本效益，应被视为一种治疗方式。
■为了比较15％三氯乙酸（TCA）果皮的功效和安全性，35%乙醇酸(GA)果皮,和Q开关Nd-YAG激光器在MA。
■打开，前瞻性研究进行了2年，在满足标准之后，随机分为三组.A组:15%TCA剥离;B组:35%GA剥离;C组:Q开关Nd-YAG激光。每月一次重复该程序，共进行六次。每次访问,患者根据以下参数进行评分：颜色评分，视觉模拟评分(VAS)，医师全球评估(PGA)量表，主观改进,和不利影响。
■共有75名患者（每组25名患者）完成了治疗。研究人群的平均年龄为35.68±9.8岁，男女比例为11.5:1。A组颜色评分的平均变化（1.68）更大，其次是C组(1.4)，其次是B组（1.16）。类似的结果是通过主观改进注意到的，VAS,和PGA。A组的不良事件更多，其次是C组，其次是B组。无患者出现永久性不良事件。
■TCA剥离显示优于Nd-YAG激光和乙醇酸剥离的结果。TCA剥离具有良好的可接受性，具有成本效益，应被视为一种治疗方式。
